CAJ | 학술논문

目的：观察胱抑素C（Cys C）能否预测终末期肾病患者心血管事件的发生。方法收集终末期肾病患者67例，在其入选时测定Cys C、Scr、BUN、LDL-C、HDL-C、Hb、Alb和CRP，观察心血管事件发生情况。结果胱抑素C与血BUN（ r ＝0後．527， P ＜0．05），SCr（ r ＝0．491， P ＜0．05）呈正相关。与年龄（ r ＝-0．326， P ＝0．05），eGFR （r ＝-0．499， P ＜0．005）呈负相关。对心血管事件的Kaplan-Meier生存分析提示高，Cys C水平组（≥3．14 mg/L）比较低Cys C水平组（＜3．14 mg/L）有更高的无事件生存率（ P ＝0．028）。在单变量分析中，Cys C能有效预测心血管事件的发生（OR＝2．622，95％CI 1．241～5．518， P ＝0．010）。结论血清Cys C可能成为终末期肾病患者的心血管事件的独立标志物。可能成为预测心血管事件的一个新角色。
목적：관찰광억소C（Cys C）능부예측종말기신병환자심혈관사건적발생。방법수집종말기신병환자67례，재기입선시측정Cys C、Scr、BUN、LDL-C、HDL-C、Hb、Alb화CRP，관찰심혈관사건발생정황。결과광억소C여혈BUN（ r ＝0후．527， P ＜0．05），SCr（ r ＝0．491， P ＜0．05）정정상관。여년령（ r ＝-0．326， P ＝0．05），eGFR （r ＝-0．499， P ＜0．005）정부상관。대심혈관사건적Kaplan-Meier생존분석제시고，Cys C수평조（≥3．14 mg/L）비교저Cys C수평조（＜3．14 mg/L）유경고적무사건생존솔（ P ＝0．028）。재단변량분석중，Cys C능유효예측심혈관사건적발생（OR＝2．622，95％CI 1．241～5．518， P ＝0．010）。결론혈청Cys C가능성위종말기신병환자적심혈관사건적독립표지물。가능성위예측심혈관사건적일개신각색。
Objective To investigate the role of serum cystatin C for prediction of cardiovascular events .Methods This study included 67 end stage renal disease patients .The following laboratory data were obtained:cystatin C, creatinine, blood urea nitrogen (BUN), lipid profile, hemoglobin, albumin and C reactive protein (CRP) levels were measured at the point of enrollment.Results Cystatin C and blood BUN ( r =0.527, P <0.05), SCr ( r =0.491, P <0.05) were posi-tively correlated.With age ( r =-0.326, P =0.05), eGFR ( r =-0.499, P <0.005) were negatively correlated.Cardi-ovascular events, Kaplan Meier survival analysis showed that the Cys C levels (≥3.14 mg/L) group have a higher event-free survival rate than Cys C levels relatively low (<3.14 mg/L) group ( P =0.028).In univariate analysis, Cys C can effec-tively predict the occurrence of cardiovascular events (OR =2.622, 95%CI 1.241-5.518, P =0.010).Conclusion Serum Cys C could become an independent marker for ESRD patients with cardiovascular events .It may become a new factor to predict cardiovascular events .