CAJ | 학술논문

目的：探讨第三脑室脊索样胶质瘤的临床、影像及病理学特点。方法回顾1例第三脑室脊索样胶质瘤患者的诊断和治疗过程，并结合文献进行分析。结果第三脑室脊索样胶质瘤影像学上主要表现为三脑室及鞍上占位影，均匀强化，边缘清晰。组织学上肿瘤呈均匀弥漫分布，簇状、条索状上皮样细胞埋在空泡状黏液样基质中，肿瘤间隔及周边间质内出现特征性淋巴细胞、浆细胞浸润。瘤细胞缺乏多形性、核分裂及坏死。免疫组化染色示GFAP弥漫性强阳性。手术全切是目前主要治疗措施，预后介于良、恶性之间。结论第三脑室脊索样胶质瘤是一种具有独特临床、组织病理学、免疫表型和电镜特点的罕见中枢神经系统肿瘤，容易误诊。病理确诊主要是根据肿瘤特定的生长部位、脊索样组织结构和免疫组化GFAP弥漫强阳性。
목적：탐토제삼뇌실척색양효질류적림상、영상급병이학특점。방법회고1례제삼뇌실척색양효질류환자적진단화치료과정，병결합문헌진행분석。결과제삼뇌실척색양효질류영상학상주요표현위삼뇌실급안상점위영，균균강화，변연청석。조직학상종류정균균미만분포，족상、조색상상피양세포매재공포상점액양기질중，종류간격급주변간질내출현특정성림파세포、장세포침윤。류세포결핍다형성、핵분렬급배사。면역조화염색시GFAP미만성강양성。수술전절시목전주요치료조시，예후개우량、악성지간。결론제삼뇌실척색양효질류시일충구유독특림상、조직병이학、면역표형화전경특점적한견중추신경계통종류，용역오진。병리학진주요시근거종류특정적생장부위、척색양조직결구화면역조화GFAP미만강양성。
Objective To investigate the clinical , imaging and pathological features of the third ventricle chor glioma.Methods This paper investigated and reviewed the clinic pathology feature of a case of chordoid glioma of the third ventricle by light-microscopy , electron microscopy , and immunohistochemistry study , and reviewed the literatures .Results Glioma of the third ventricle chordoid imaging mainly as placeholders shadow on the third ventricle and saddle , homogeneous enhancement, edge clarity.Histologically, the tumor showed diffuse evenly distributed , clustered, cord-like epithelial cells buried in the vacuoles myxoid matrix , the interval between tumor cells and the surrounding endoplasmic characteristic with plasma cell infiltration .Tumor cells lacking pleomorphic mitotic and necrotic .GFAP immunohistochemistry shows diffuse strongly positive .Complete removal is the main treatment , prognosis between benign and malignant .Conclusion Chordoid glioma of the third ventricle is a unique clinical , histopathological , immunological phenotype characterized by electron micros-copy and rare central nervous system tumors , easily misdiagnosed .Pathological diagnosis is mainly based on the growth of tumor -specific parts chordoid organizational structure and GFAP immunohistochemistry diffuse strongly positive .