CAJ | 학술논문

目的：观察乌灵胶囊（ WL）预防脑梗死后抑郁和认知障碍患者临床疗效。方法脑梗死患者435例随机分为WL组和对照组，在常规治疗基础上，WL组口服WL胶囊3粒，每日3次；对照组口服安慰剂胶囊3粒，每日3次，疗程均6周。分别于治疗前及治疗后1、2、4、6周末及3月末以HAMD、MoCA、NIHSS评分进行评定，并观察抑郁发生情况。结果（1）抑郁发病率：治疗2、4周末，WL组抑郁发病率均低于对照组，但差异无统计学意义（ P ＞0构．05），治疗6周末及3个月末，WL组抑郁发病率均低于对照组，且差异有统计学意义（ P ＜0．05）。（2）HAMD评分：2组治疗后均较治疗前升高（ P ＜0．05），且WL组2、4、6周末及3个月末均低于对照组（ P ＜0．05）。（3）NIHSS评分：除第1周末外，2组治疗后NIHSS评分均较治疗前下降（ P ＜0．05），且WL组均优于对照组（ P ＜0．05）。（4）Mo-CA评分：2组治疗后4、5周末及3个月末MoCA评分均较治疗前升高（ P ＜0．05），且WL组均高于对照组（ P ＜0．05）。（5）不良反应：2组均未发生严重不良反应。结论乌灵胶囊防治脑梗死后抑郁及认知障碍疗效明显。
목적：관찰오령효낭（ WL）예방뇌경사후억욱화인지장애환자림상료효。방법뇌경사환자435례수궤분위WL조화대조조，재상규치료기출상，WL조구복WL효낭3립，매일3차；대조조구복안위제효낭3립，매일3차，료정균6주。분별우치료전급치료후1、2、4、6주말급3월말이HAMD、MoCA、NIHSS평분진행평정，병관찰억욱발생정황。결과（1）억욱발병솔：치료2、4주말，WL조억욱발병솔균저우대조조，단차이무통계학의의（ P ＞0구．05），치료6주말급3개월말，WL조억욱발병솔균저우대조조，차차이유통계학의의（ P ＜0．05）。（2）HAMD평분：2조치료후균교치료전승고（ P ＜0．05），차WL조2、4、6주말급3개월말균저우대조조（ P ＜0．05）。（3）NIHSS평분：제제1주말외，2조치료후NIHSS평분균교치료전하강（ P ＜0．05），차WL조균우우대조조（ P ＜0．05）。（4）Mo-CA평분：2조치료후4、5주말급3개월말MoCA평분균교치료전승고（ P ＜0．05），차WL조균고우대조조（ P ＜0．05）。（5）불량반응：2조균미발생엄중불량반응。결론오령효낭방치뇌경사후억욱급인지장애료효명현。
Objective To observe the curative effects of Wuling capsule ( WL) in preventing depression after cere-bral infarction ( DCI) and cognitive disorder .Methods Cerebral infarction 435 cases were randomly divided into two groups ( WL group and control group ) , based on the conventional treatment , WL group received oral WL capsules , 3 times a day;the control group was treated with placebo capsules , 3 times daily for all six weeks .Before and after treatment with 1st, 2nd, 4th, 6th weekends and at the end of 3 months, HAMD, MoCA, NIHSS score were assessed and observed the occurrence of depression .Results (1) The incidence of depression:Treatment at 2nd, 4th weekend, incidence rates of depression in WL group were lower than the control group , but the difference was not statistically significant ( P >0.05), and 6 weeks to 3 months after treatment , incidence rates of depression in WL group lower than the control group , and the difference was statisti-cally significant ( P <0.05).(2) HAMD score:2 groups after treatment increased than before treatment ( P <0.05), and in the WL group, at 2nd, 4th, 6th weekend and at the end of 3 months, the score were lower than the control group ( P <0.05).(3) NIHSS score:In addition to the first weekend , after treatment, the two groups'NIHSS score decreased than be-fore treatment ( P <0.05), and WL groups were better than the control group ( P <0.05).(4) MoCA Rating:after treat-ment, at 4th, 5th weekend and at the end of 3 months, the 2 groups'MoCA scores were elevated before treatment ( P <0.05), and WL groups were higher ( P <0.05).(5) Adverse reactions: two groups were not found serious adverse reac-tions.Conclusion It showed obviously effect of Wuling capsule on preventing DCI and neurological deficit .