CAJ | 학술논문

目的：探讨健康体检人群脉搏波传导速度（ PWV）与视网膜动脉硬化的相关性。方法2011年1月-2012年12月行身体检查者2480例，分析其视网膜动脉硬化的发生率，并探讨视网膜动脉硬化相关危险因素及其与PWV的相关性。结果2480例正常体检者中出现视网膜动脉硬化138例（5 J．56％）为观察组，其中I级病变95例（3．83％），II级病变21例（0．85％），III级病变17例（0．69％），IV级病变5例（0．20％）。与非视网膜动脉硬化组（对照组）相比，观察组平均年龄、糖化血红蛋白（ HbAlc ）、总胆固醇（ TC）、三酰甘油（ TG）、低密度脂蛋白胆固醇（ LDL-C）、收缩压（ SBP ）、PWV 水平显著增加，高密度脂蛋白胆固醇（ HDL-C ）水平显著降低，差异有统计学意义（ P ＜0．05），而性别、体质量指数（BMI）、舒张压（DBP）差异均无统计学意义（ P ＞0．05）。随着视网膜动脉硬化程度的加深，PWV水平显著增加，单因素分析表明PWV与视网膜硬化水平呈正相关（ r ＝0．451， P ＜0．05）。 Logistic多因素回归分析表明，PWV、HbAlc、SBP、TG是视网膜动脉硬化的独立危险因子，OR（95％CI）分别为1．984（1．021～5．201）、1．658（1．187～3．964）、1．587（1．085～3．412）、1．375（1．052～4．101）。结论脉搏波传导速度与视网膜动脉硬化程度有密切的关系，是视网膜动脉硬化的独立危险因子，对视网膜动脉硬化具有一定的预测价值。
목적：탐토건강체검인군맥박파전도속도（ PWV）여시망막동맥경화적상관성。방법2011년1월-2012년12월행신체검사자2480례，분석기시망막동맥경화적발생솔，병탐토시망막동맥경화상관위험인소급기여PWV적상관성。결과2480례정상체검자중출현시망막동맥경화138례（5 J．56％）위관찰조，기중I급병변95례（3．83％），II급병변21례（0．85％），III급병변17례（0．69％），IV급병변5례（0．20％）。여비시망막동맥경화조（대조조）상비，관찰조평균년령、당화혈홍단백（ HbAlc ）、총담고순（ TC）、삼선감유（ TG）、저밀도지단백담고순（ LDL-C）、수축압（ SBP ）、PWV 수평현저증가，고밀도지단백담고순（ HDL-C ）수평현저강저，차이유통계학의의（ P ＜0．05），이성별、체질량지수（BMI）、서장압（DBP）차이균무통계학의의（ P ＞0．05）。수착시망막동맥경화정도적가심，PWV수평현저증가，단인소분석표명PWV여시망막경화수평정정상관（ r ＝0．451， P ＜0．05）。 Logistic다인소회귀분석표명，PWV、HbAlc、SBP、TG시시망막동맥경화적독립위험인자，OR（95％CI）분별위1．984（1．021～5．201）、1．658（1．187～3．964）、1．587（1．085～3．412）、1．375（1．052～4．101）。결론맥박파전도속도여시망막동맥경화정도유밀절적관계，시시망막동맥경화적독립위험인자，대시망막동맥경화구유일정적예측개치。
Objective To explore the correlation between healthy people pulse wave velocity ( PWV) and retinal ar-teriosclerosis.Methods Between January 2011 to December 2012, 2 480 people underwent physical examination , analysis of the incidence of retinal arteriosclerosis , retinal arteriosclerosis and to explore the risk factors and the correlation with PWV . Results There were 138 cases of retinal arteriosclerosis appeared in normal volunteers of 2 480 cases (5.56%) served as observation group , which grade I lesions in 95 cases (3.83%), grade II lesions 21 cases (0.85%), grade III lesions in 17 cases (0.69%), grade IV lesions in 5 cases (0.20%).Compared with non-retinal arteriosclerosis group (control group) , the average age of the observation group , glucose glycated proteins (HbAlc), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), systolic blood pressure (SBP), PWV levels were significantly increased, the difference was statistically significant ( P <0.05), while gender, body mass in-dex (BMI), diastolic blood pressure (DBP) were not significantly different ( P >0.05).With the deepening of retinal arte-riosclerosis, PWV was significantly increased , univariate analysis showed that retinal sclerosis PWV was positively correlated ( r =0.451, P <0.05).Logistic regression analysis showed that , PWV, HbAlc, SBP, TG are independent risk factors for retinal arteriosclerosis, OR (95%CI) were 1.984 (1.021-5.201), 1.658 (1.187-3.964), 1.587 (1.085-3.412), 1.375 (1.052-4.101).Conclusion Pulse wave velocity and the retina is closely related to the degree of atherosclerosis , are independent risk factors for retinal arteriosclerosis , have some predictive value .