CAJ | 학술논문

目的：探讨坎地沙坦联合比索洛尔治疗中青年高血压病左心室肥厚的临床疗效。方法中青年高血压病左心室肥厚患者126例随机分为对照组62例与观察组64例，对照组患者口服比索洛尔，观察组患者口服坎地沙坦联合比索洛尔，疗程均6个月。比较2组降压效果、超声心动图指标及血清炎性因子的改变。结果疗程结束后，2组患者血压均显著下降（ P ＜0%．05），且观察组血压均显著低于对照组（ P ＜0．05）；2组LVEDd、LVPWT、IVST、LVMI、LVEF及E/A均显著改善，且观察组均优于对照组（ P ＜0．05）；2组血清hs-CRP、IL-6及NT-proBNP均显著降低（ P ＜0．05），且观察组改善优于对照组（ P ＜0．05）。结论坎地沙坦联合比索洛尔可显著降低中青年高血压患者血清炎性因子水平，其逆转左室肥厚作用考虑与抗炎作用有关，是独立于降压作用的。
목적：탐토감지사탄연합비색락이치료중청년고혈압병좌심실비후적림상료효。방법중청년고혈압병좌심실비후환자126례수궤분위대조조62례여관찰조64례，대조조환자구복비색락이，관찰조환자구복감지사탄연합비색락이，료정균6개월。비교2조강압효과、초성심동도지표급혈청염성인자적개변。결과료정결속후，2조환자혈압균현저하강（ P ＜0%．05），차관찰조혈압균현저저우대조조（ P ＜0．05）；2조LVEDd、LVPWT、IVST、LVMI、LVEF급E/A균현저개선，차관찰조균우우대조조（ P ＜0．05）；2조혈청hs-CRP、IL-6급NT-proBNP균현저강저（ P ＜0．05），차관찰조개선우우대조조（ P ＜0．05）。결론감지사탄연합비색락이가현저강저중청년고혈압환자혈청염성인자수평，기역전좌실비후작용고필여항염작용유관，시독립우강압작용적。
Objective To explore the clinical effect of candesartan cilexetil combine with bisoprolol in treatment of middle age and youth hypertension complicated with left ventricular hypertrophy .Methods Young hypertensive patients with left ventricular hypertrophy ( n =126) were randomly divided into control group of 62 patients, observation group of 64 pa-tients.In the control group , patients were treated with bisoprolol , observation group were combined oral bisoprolol candesar-tan, regimens 6 months.Antihypertensive effect of two groups were compared , echocardiographic parameters and serum in-flammatory factors change .Results After the treatment, two groups patients'blood pressure were significantly decreased (P <0.05), and blood pressure of the observation group were significantly lower than the control group ( P <0.05);2 groups'LVEDd, LVPWT, IVST, LVMI, LVEF and E/A were significantly improved , and the observation group was better than the control group ( P <0.05);2 groups'serum hs-CRP, IL-6 and NT-proBNP were significantly lower ( P <0.05), and the improvement of the observation group was better than the control group ( P <0.05).Conclusion Bisoprolol and candesartan significantly reduced serum inflammatory cytokine levels in youth patients with hypertension , the reversal role of left ventricular hypertrophy were considered related to anti-inflammatory effects, and is independent from antihypertensive effect.