CAJ | 학술논문

目的：通过总结近年来扬州地区结核与非结核分枝杆菌耐药现状，为该地区肺结核病化疗选择药物提供参考依据。方法通过鉴别培养基对硝基苯甲酸（PNB）和噻吩-2-羟酸肼（TCH）做分枝杆菌菌型初筛鉴别，绝对浓度法检测耐药。结果结核分枝杆菌群分离率为94.63%（141/149），非结核分枝杆菌分离率为5.37%（8/149）；结核分枝杆菌群耐多药率14.18%，总耐药率49.65%。非结核分枝杆菌耐多药率87.5%，总耐药率100%。结核分枝杆菌群以耐TH1321、SM、INH和RFP多见，非结核分枝杆菌高耐药与结核分枝杆菌群相似。结论本地区肺结核以结核分枝杆菌群为主，耐多药率及总耐药率高于全国水平，非结核分枝杆菌分离率较低，但临床应十分警惕。
목적：통과총결근년래양주지구결핵여비결핵분지간균내약현상，위해지구폐결핵병화료선택약물제공삼고의거。방법통과감별배양기대초기분갑산（PNB）화새분-2-간산정（TCH）주분지간균균형초사감별，절대농도법검측내약。결과결핵분지간균군분리솔위94.63%（141/149），비결핵분지간균분리솔위5.37%（8/149）；결핵분지간균군내다약솔14.18%，총내약솔49.65%。비결핵분지간균내다약솔87.5%，총내약솔100%。결핵분지간균군이내TH1321、SM、INH화RFP다견，비결핵분지간균고내약여결핵분지간균군상사。결론본지구폐결핵이결핵분지간균군위주，내다약솔급총내약솔고우전국수평，비결핵분지간균분리솔교저，단림상응십분경척。
Objective To summarize situation of mycobacterium tuberculosis and nontuberculosis mycobacteria drug re-sistance, to provide the reference basis for the drug choice of tuberculosis chemotherapy. Methods Differential medium (PNB) and thiophene p-nitrobenzoic acid - 2 - hydroxy acid hydrazine (TCH) were done early screening to identify bacteria mycobacterium type,absolute concentration method of detection of drug resistance. Results Tuberculosis separation rate of mycobacterium was 94.63% (141/149),the separation rate of nontuberculosis mycobacteria was 5.37% (8/149),group of mul-tidrug-resistant mycobacterium tuberculosis rate was 14.18%,49.65% of the total resistance. Of multidrug-resistant nontubercu-losis mycobacteria rate was 87.5%, the total resistance rate was 100%. Resistance of mycobacterium tuberculosis in TH1321 , SM,INH and RFP,nontuberculosis mycobacteria was similar to mycobacterium tuberculosis group of high drug resistance. Conclusion Tuberculosis in Yangzhou mainly is mycobacterium tuberculosis,the region of multi-drug resistant rate and total resistance is higher than the national level,the separation rate of nontuberculosis mycobacteria is low,but should be very alert.