CAJ | 학술논문

目的：探讨锌指转录因子Slug蛋白（snail-2）在结直肠腺癌中的表达及其意义。方法采用免疫组织化学Envision方法检测Slug蛋白在87例结直肠腺癌、30例腺瘤、30例增生性息肉及30例癌旁组织中的表达，分析其与临床病理参数的关系。结果 Slug蛋白在结直肠腺癌组织中的阳性率为42．5％（37/87），与Slug蛋白在癌旁组织（6．7％，2/30）和增生性息肉（16．7％，5/30）以及腺瘤（23．3％，7/30）中的表达阳性率相比，差异有统计学意义（P＜0．05）。在结直肠腺癌组织中，Slug蛋白的表达与结直肠癌分化程度、浸润深度、淋巴结转移、TNM分期有关（P＜0．05），与年龄、性别及肿瘤的发生部位无关（P＞0．05）。结论 Slug蛋白与结直肠腺癌的发生和发展、侵袭转移有关，对于结直肠腺癌的诊断及预后评估具有一定的指导作用。
목적：탐토자지전록인자Slug단백（snail-2）재결직장선암중적표체급기의의。방법채용면역조직화학Envision방법검측Slug단백재87례결직장선암、30례선류、30례증생성식육급30례암방조직중적표체，분석기여림상병리삼수적관계。결과 Slug단백재결직장선암조직중적양성솔위42．5％（37/87），여Slug단백재암방조직（6．7％，2/30）화증생성식육（16．7％，5/30）이급선류（23．3％，7/30）중적표체양성솔상비，차이유통계학의의（P＜0．05）。재결직장선암조직중，Slug단백적표체여결직장암분화정도、침윤심도、림파결전이、TNM분기유관（P＜0．05），여년령、성별급종류적발생부위무관（P＞0．05）。결론 Slug단백여결직장선암적발생화발전、침습전이유관，대우결직장선암적진단급예후평고구유일정적지도작용。
Objective To explore the expression and significance of the zinc finger protein Slug in colorectal adenocarcinoma tissues. Methods Expression of Slug in the biopsy tissues derived from colorectal carcinoma ( n=87), adenoma (n=30), polyps (n=30), and tissues adjacent to carcinoma (n=30) were detected by immunohistochemistry as-say using Envision technique. Relationships between Slug and clinical and pathological profiles were analyzed. Re-sults Positive expression of Slug was found in 42.5% of the colorectal adenocarcinoma tissues (37/87), which was significantly higher (P<0.05) than that in colorectal adenocarcinoma adjacent tissues (6.7%, 2/30), hyperplastic polyps (16.7%, 5/30) and adenoma (23.3%, 7/30). Significant correlations were found between Slug expression and tumor dif-ferentiation, depth of infiltration, lymph node metastasis and TNM stages (all P<0.05), but not the age, gender or the location of tumor (all P>0.05). Conclusion Slug protein may be associated with the pathogenesis, development, inva-sion and metastasis of colorectal adenocarcinoma and can be regarded as a valuable indicator for the diagnosis, treat-ment and prognosis of colorectal adenocarcinoma.