中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
11期
52-53,54
,共3页
吗啡%芬太尼%术前鞘内注射%子宫切除%镇痛
嗎啡%芬太尼%術前鞘內註射%子宮切除%鎮痛
마배%분태니%술전초내주사%자궁절제%진통
Morphine%Fentanyl%Preoperative intrathecal injection%Hysterectomy%Analgesic
目的：评价不同剂量吗啡联合芬太尼术前鞘内注射对子宫切除术后的镇痛效果。方法：选取2011年10月-2012年11月在本院择期行全子宫切除术的86例患者，按照随机数字表法将其分成联合1组和联合2组各43例，联合1组采用0.2 mg吗啡+25μg芬太尼，联合2组采用0.5 mg吗啡+15μg芬太尼，采用视觉模拟评分法对两组患者术后疼痛情况进行评价，比较两组患者不良反应发生和补救镇痛情况。结果：联合1组的排气时间明显短于联合2组，差异有统计学意义（P<0.05）；各时间点，联合1组的VAS评分均明显低于联合2组，差异均有统计学意义（P<0.05）；联合1组不良反应发生率均低于联合2组，差异均具有统计学意义（P<0.05），联合1组补救镇痛率为2.3%，低于联合2组的7.0%，但差异无统计学意义（P>0.05）。结论：0.2 mg吗啡+25μg芬太尼用于子宫切除患者术前鞘内镇痛效果较佳，不良反应发生率低，安全性较好，且有助于术后胃肠功能恢复，值得临床推广。
目的：評價不同劑量嗎啡聯閤芬太尼術前鞘內註射對子宮切除術後的鎮痛效果。方法：選取2011年10月-2012年11月在本院擇期行全子宮切除術的86例患者，按照隨機數字錶法將其分成聯閤1組和聯閤2組各43例，聯閤1組採用0.2 mg嗎啡+25μg芬太尼，聯閤2組採用0.5 mg嗎啡+15μg芬太尼，採用視覺模擬評分法對兩組患者術後疼痛情況進行評價，比較兩組患者不良反應髮生和補救鎮痛情況。結果：聯閤1組的排氣時間明顯短于聯閤2組，差異有統計學意義（P<0.05）；各時間點，聯閤1組的VAS評分均明顯低于聯閤2組，差異均有統計學意義（P<0.05）；聯閤1組不良反應髮生率均低于聯閤2組，差異均具有統計學意義（P<0.05），聯閤1組補救鎮痛率為2.3%，低于聯閤2組的7.0%，但差異無統計學意義（P>0.05）。結論：0.2 mg嗎啡+25μg芬太尼用于子宮切除患者術前鞘內鎮痛效果較佳，不良反應髮生率低，安全性較好，且有助于術後胃腸功能恢複，值得臨床推廣。
목적：평개불동제량마배연합분태니술전초내주사대자궁절제술후적진통효과。방법：선취2011년10월-2012년11월재본원택기행전자궁절제술적86례환자，안조수궤수자표법장기분성연합1조화연합2조각43례，연합1조채용0.2 mg마배+25μg분태니，연합2조채용0.5 mg마배+15μg분태니，채용시각모의평분법대량조환자술후동통정황진행평개，비교량조환자불량반응발생화보구진통정황。결과：연합1조적배기시간명현단우연합2조，차이유통계학의의（P<0.05）；각시간점，연합1조적VAS평분균명현저우연합2조，차이균유통계학의의（P<0.05）；연합1조불량반응발생솔균저우연합2조，차이균구유통계학의의（P<0.05），연합1조보구진통솔위2.3%，저우연합2조적7.0%，단차이무통계학의의（P>0.05）。결론：0.2 mg마배+25μg분태니용우자궁절제환자술전초내진통효과교가，불량반응발생솔저，안전성교호，차유조우술후위장공능회복，치득림상추엄。
Objective:To investigate the analgesic efficacy after hysterectomy of preoperative intrathecal injection of different doses of morphine and fentanyl.Method:86 patients underwent complete hysterectomy in our hospital were selected from October 2011 to November 2012.All cases were randomly divided into the combination group 1 and the combination group 2,43 cases in each group.The combination group 1 was given 0.2 mg morphine+25μg fentanyl,the combination group 2 was given 0.5 mg morphine+15μg fentanyl.Postoperative pains of the two groups were evaluated by using visual analogue scale.Adverse events and remedial analgesia situation were compared between the two groups.Result:The exhaust time of the combination group 1 was significantly shorter than combination group 2,the difference was statistically significant (P<0.05).Each time point,the VAS scores of combination group 1 were significantly lower than combination group 2,the differences were statistically significant(P<0.05).The adverse reaction rates of combination group 1 were significantly lower than combination group 2,the differences were statistically significant(P<0.05).The remedy analgesia rate of combination group 1 was 2.3%,which was lower than combination group 2,but the difference was not statistically significant(P>0.05). Conclusion:The analgesic efficacy after hysterectomy of preoperative intrathecal injection 0.2 mg morphine+25μg fentanyl is better,low incidence of adverse reactions,good safety,and helpful to the recovery of postoperative gastrointestinal function,it is worth the clinical promotion.
