中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
11期
47-48,49
,共3页
区域麻醉%咪唑安定%镇静深度
區域痳醉%咪唑安定%鎮靜深度
구역마취%미서안정%진정심도
Regional anesthesia%Imidazole stability%The depth of sedation
目的：探讨分析咪唑安定辅助区域麻醉的合适镇静深度及用量。方法：选取2012年10月-2013年4月本院接诊的240例行上下肢以及下腹部手术患者作为研究对象，按照随机数字表法将其分为A、B、C组各80例，行区域麻醉后，对患者使用咪唑安定分别至OAA/S标准Ⅳ、Ⅲ、Ⅱ级镇静深度，观察用药后患者HR、MAP以及SpO2的变化，统计患者术中烦躁的发生率及遗忘率以及各组患者咪唑安定的平均用量。结果：三组患者达到Ⅳ、Ⅲ、Ⅱ级镇静深度的咪唑安定用量为（0.041±0.022）、（0.062±0.033）、（0.132±0.031）mg/kg。三组患者的术中事件遗忘率比较差异均无统计学意义（P>0.05），C组患者烦躁的发生率25.0%明显高于A组的2.5%和B组的3.75%，差异均有统计学意义（P<0.05）；三组患者的血压均有一定程度的下降，C组SpO2有明显下降，与A、B组比较差异均有统计学意义（P<0.05）。结论：咪唑安定辅助区域麻醉最佳用量为（0.062±0.033）mg/kg，最佳镇静深度为OAA/SⅢ级。
目的：探討分析咪唑安定輔助區域痳醉的閤適鎮靜深度及用量。方法：選取2012年10月-2013年4月本院接診的240例行上下肢以及下腹部手術患者作為研究對象，按照隨機數字錶法將其分為A、B、C組各80例，行區域痳醉後，對患者使用咪唑安定分彆至OAA/S標準Ⅳ、Ⅲ、Ⅱ級鎮靜深度，觀察用藥後患者HR、MAP以及SpO2的變化，統計患者術中煩躁的髮生率及遺忘率以及各組患者咪唑安定的平均用量。結果：三組患者達到Ⅳ、Ⅲ、Ⅱ級鎮靜深度的咪唑安定用量為（0.041±0.022）、（0.062±0.033）、（0.132±0.031）mg/kg。三組患者的術中事件遺忘率比較差異均無統計學意義（P>0.05），C組患者煩躁的髮生率25.0%明顯高于A組的2.5%和B組的3.75%，差異均有統計學意義（P<0.05）；三組患者的血壓均有一定程度的下降，C組SpO2有明顯下降，與A、B組比較差異均有統計學意義（P<0.05）。結論：咪唑安定輔助區域痳醉最佳用量為（0.062±0.033）mg/kg，最佳鎮靜深度為OAA/SⅢ級。
목적：탐토분석미서안정보조구역마취적합괄진정심도급용량。방법：선취2012년10월-2013년4월본원접진적240례행상하지이급하복부수술환자작위연구대상，안조수궤수자표법장기분위A、B、C조각80례，행구역마취후，대환자사용미서안정분별지OAA/S표준Ⅳ、Ⅲ、Ⅱ급진정심도，관찰용약후환자HR、MAP이급SpO2적변화，통계환자술중번조적발생솔급유망솔이급각조환자미서안정적평균용량。결과：삼조환자체도Ⅳ、Ⅲ、Ⅱ급진정심도적미서안정용량위（0.041±0.022）、（0.062±0.033）、（0.132±0.031）mg/kg。삼조환자적술중사건유망솔비교차이균무통계학의의（P>0.05），C조환자번조적발생솔25.0%명현고우A조적2.5%화B조적3.75%，차이균유통계학의의（P<0.05）；삼조환자적혈압균유일정정도적하강，C조SpO2유명현하강，여A、B조비교차이균유통계학의의（P<0.05）。결론：미서안정보조구역마취최가용량위（0.062±0.033）mg/kg，최가진정심도위OAA/SⅢ급。
Objective:To investigate and analyze the depth of sedation and appropriate dosage in regional anesthesia with midazolam.Method:240 patients underwent upper and lower limbs and abdominal operation in our hospital from October 2012 to April 2013 were selected as research objects,they were randomly divided into group A,group B and group C,80 cases in each group.After regional anesthesia,the patients with imidazole were stable to OAA/S standardⅣ,Ⅲ,Ⅱlevel of sedation depth.HR,MAP and SpO2 changes of the patients after treatment were observed,the incidence of irritable and forgetting rate and the average dosage of midazolam in each group were counted.Result:Three groups of patients achievedⅣ,Ⅲ,Ⅱsedation of midazolam dosage was(0.041±0.022),(0.062±0.033),(0.132±0.031)mg/kg respectively,there was no statistically significant difference in the intraoperative amnesia rate of the three groups(P>0.05),the irritable rate of group C was 25.0%,it was higher than 2.5%in group A and 3.75%in group B,the differences were statistically significant (P<0.05),blood pressure decreased in patients of the 3 groups to a certain extent,SpO2 of group C decreased significantly, compared with group A and group B,the differences were statistically significant(P<0.05).Conclusion:The optimal dosage of midazolam in regional anesthesia is(0.062±0.033)mg/kg,the optimal sedative depth is OAA/S gradeⅢ.
