CAJ | 학술논문

目的：观察调气止泻方在应用含氟尿嘧啶类化疗方案时对化疗相关性腹泻（CID）的预防作用。方法：采用前瞻性非随机对照研究方法，选择符合纳入标准的胃肠道恶性肿瘤住院患者按治疗方案分为调气止泻方干预组和空白对照组，以CID发生率及发生 CID等级、主要症状、卡氏评分作为衡量疗效的指标，对调气止泻方预防CID的效果做出临床评估。结果：共纳入合格病例81例，其中试验组40例，空白对照组41例。（1）第1次化疗后，试验组CID发生率为25．0％，对照组CID发生率为46．3％，两组间差异没有统计学意义（P＞0．05）；第2次化疗后，试验组CID发生率为15．0％，对照组CID发生率为73．2％，两组间差异有统计学意义（P＜0．05）。（2）两组在试验前后症候评分情况：试验组症候疗效评价进步15例（37．5％），对照组症候疗效评价进步1例（2．4％），两组间差异有统计学意义（P＜0．05）。（3）两组在试验前后卡氏评分方面：试验组降低1例（2．5％），稳定32例（80．0％），提高7例（17．5％）；对照组降低7例（17．1％），稳定29例（70．0％），提高5例（12．2％）。结论：调气止泻方可预防CID发生，对改善临床症状和KPS评分也有一定作用。
목적：관찰조기지사방재응용함불뇨밀정류화료방안시대화료상관성복사（CID）적예방작용。방법：채용전첨성비수궤대조연구방법，선택부합납입표준적위장도악성종류주원환자안치료방안분위조기지사방간예조화공백대조조，이CID발생솔급발생 CID등급、주요증상、잡씨평분작위형량료효적지표，대조기지사방예방CID적효과주출림상평고。결과：공납입합격병례81례，기중시험조40례，공백대조조41례。（1）제1차화료후，시험조CID발생솔위25．0％，대조조CID발생솔위46．3％，량조간차이몰유통계학의의（P＞0．05）；제2차화료후，시험조CID발생솔위15．0％，대조조CID발생솔위73．2％，량조간차이유통계학의의（P＜0．05）。（2）량조재시험전후증후평분정황：시험조증후료효평개진보15례（37．5％），대조조증후료효평개진보1례（2．4％），량조간차이유통계학의의（P＜0．05）。（3）량조재시험전후잡씨평분방면：시험조강저1례（2．5％），은정32례（80．0％），제고7례（17．5％）；대조조강저7례（17．1％），은정29례（70．0％），제고5례（12．2％）。결론：조기지사방가예방CID발생，대개선림상증상화KPS평분야유일정작용。
Objective To observe the prevention of regulating qi and stopping diarrhea formule on the fluorouracil (5-FU, Xeloda, etc.) chemotherapy-related diarrhea (CID). Methods Adopt the study method on prospective, non-randomized and controlled. Inpatients diagnosed gastrointestinal malignancy according to the inclusion criteria, were selected and divided into experimental groups and control groups by treatment programs. 81 cases were brought into the program, including 40 cases in experimental group, 41 cases in control group. Incidence of CID, the occurrence of CID grade, the main symptoms, Karnofsky performance status were measured as efficacy indicators. Then we analyzed the role of regulating qi and stopping diarrhea formule in the reduction of chemotherapy poison. Results (1) CID situation occurs: after the first chemotherapy, the CID incidence of the experimental group was 25.0%, and that in the control group was 46.3%. There was no significant difference between two groups (P>0.05). After the second chemotherapy, CID incidence of the experimental group was 15.0%, while the control group′s was 73.2%. There was significant difference between two groups (P<0.05). (2) Symptom scores situation:symptom scores progress incidence of the test group was 37.5%, the control group′s was 2.4%, and there was significant difference between two groups (P < 0.05). (3)Karnofsky performance: the performance of the test group Karnofsky reduced 1(2.5%) , stable 32(80.0%), increased 7(17.5%); decreased 7(17.1%) control group, stable 29 (70.0%), increased 5 (12.2%). Conclusions Regulating qi and stopping diarrhea formule plays a role in the prevention of CID and in improving the clinical symptoms of TCM and KPS scores.