CAJ | 학술논문

现有的各种全身治疗方式不能治愈转移性肾癌。外科手术是治愈肾癌的唯一手段。减瘤性肾切除术在转移性肾癌治疗中仍然扮演着重要角色,靶向治疗药物的出现为肾癌治疗方式提供了新的选择。目前关于手术前新辅助应用靶向治疗的问题主要包括治疗适应症,用药安全性,治疗效果的预期,最佳治疗持续时间三方面。该综述主要讨论以下两个问题：①晚期肾癌患者术前应用靶向药物进行新辅助治疗是否有合理的理论依据？什么类型的临床数据(病例报告,Ⅱ/Ⅲ期临床试验)支持上述指征？②应用新辅助治疗的指征及治疗安全性如何评价？
현유적각충전신치료방식불능치유전이성신암。외과수술시치유신암적유일수단。감류성신절제술재전이성신암치료중잉연분연착중요각색,파향치료약물적출현위신암치료방식제공료신적선택。목전관우수술전신보조응용파향치료적문제주요포괄치료괄응증,용약안전성,치료효과적예기,최가치료지속시간삼방면。해종술주요토론이하량개문제：①만기신암환자술전응용파향약물진행신보조치료시부유합리적이론의거？십요류형적림상수거(병례보고,Ⅱ/Ⅲ기림상시험)지지상술지정？②응용신보조치료적지정급치료안전성여하평개？
Metastatic-renal-cell-carcino-ma-can't-be-cured-by-the-existing-vari-ous-syste-mic-treat-ment-.Surgery-is-the-onl-y-means-to-cure-ki-dney-cancer-.Nephrectomy-in-still-plays-an-i-mportant-role-in-the-treat-ment-of-metastatic-ki-d-ney-cancer-,the-emergence-of-targeted-drugs-provi-des-a-ne-w-choice-for-ki-dney-cancer-treat-ments-.Current-issue-of-preoperati-ve-neoadj-uvant-applicati-ons-of-targeted-therapy-incl-udes-treat-ment-indicati-ons-,drug-safety-and-therapeutic-effects-of-expectati-ons-,and-the-best-treat-ment-durati-on-.This-revie-w-focuses-on-the-foll-o-wing-t-wo-questi-ons-:①The-preoperati-on-ad-miniatrati-on-of-neoadj-uvant-targeted-therapy-for-advanced-ki-dney-cancer-patients-have-a-reasonable-theoretical-basis---What-type-of-clinical-data-(case-report-,Ⅱ/Ⅲclinical-trials-)support-this-indicati-ons---②What's-the-indicati-ons-and-the-safety-eval-uati-on-of-ne-w-adj-uvant-target-therapy-