化工进展
化工進展
화공진전
CHEMICAL INDUSTRY AND ENGINEERING PROGRESS
2012年
6期
1306-1313
,共8页
芳胺%芳香硝基化合物%N-烷基芳胺%N-烷基化
芳胺%芳香硝基化閤物%N-烷基芳胺%N-烷基化
방알%방향초기화합물%N-완기방알%N-완기화
anilines%nitroaromatics%N-alkyl anilines%N-alkylation
N-烷基芳胺是非常重要的有机原料和精细化工中间体,广泛应用于染料、塑料、医药和农药等领域。介绍了芳胺与烷基化试剂如卤代烃、羰基化合物、醇等进行的取代烷基化反应合成N-烷基芳胺的反应机理及烷基化工艺;重点阐述了以芳香硝基化合物为原料一锅法合成N-烷基芳胺的生产工艺,分别讨论了以羰基化合物、腈、醇作为烷基化试剂的优劣,认为以醇为烷基化试剂的反应条件温和、不需要添加任何配体,具有较好的应用前景。指出开发适合以醇为烷基化试剂的选择性高的催化剂是以后的研究方向。
N-烷基芳胺是非常重要的有機原料和精細化工中間體,廣汎應用于染料、塑料、醫藥和農藥等領域。介紹瞭芳胺與烷基化試劑如滷代烴、羰基化閤物、醇等進行的取代烷基化反應閤成N-烷基芳胺的反應機理及烷基化工藝;重點闡述瞭以芳香硝基化閤物為原料一鍋法閤成N-烷基芳胺的生產工藝,分彆討論瞭以羰基化閤物、腈、醇作為烷基化試劑的優劣,認為以醇為烷基化試劑的反應條件溫和、不需要添加任何配體,具有較好的應用前景。指齣開髮適閤以醇為烷基化試劑的選擇性高的催化劑是以後的研究方嚮。
N-완기방알시비상중요적유궤원료화정세화공중간체,엄범응용우염료、소료、의약화농약등영역。개소료방알여완기화시제여서대경、탄기화합물、순등진행적취대완기화반응합성N-완기방알적반응궤리급완기화공예;중점천술료이방향초기화합물위원료일과법합성N-완기방알적생산공예,분별토론료이탄기화합물、정、순작위완기화시제적우렬,인위이순위완기화시제적반응조건온화、불수요첨가임하배체,구유교호적응용전경。지출개발괄합이순위완기화시제적선택성고적최화제시이후적연구방향。
N-alkyl anilines are widely used as synthetic intermediates for pharmaceuticals, agrochemicals,fine chemicals,bioactive compounds,and dyes chemicals.The mechanism and the research process of N-alkylation of aromatic amines with corresponding alkylating agents,such as alkyl halides,carbonyl compounds and alcohols were summarized in this paper.The one-pot synthesis of N-alkyl anilines from nitroaromatics as starting material with carbonyl compounds,nitriles and alcohols was highlighted.Recently,much attention has been paid to the use of alcohols as alkylating reagents for the N-alkylation of nitroaromatics due to the mild reaction conditions,without additional organic ligand.Therefore,the development of efficient catalyst for N-alkylation system with alcohol is still a challenging goal.
