化工进展
化工進展
화공진전
CHEMICAL INDUSTRY AND ENGINEERING PROGRESS
2012年
7期
1581-1586
,共6页
万涛%齐海山%陈云琳%闻建平
萬濤%齊海山%陳雲琳%聞建平
만도%제해산%진운림%문건평
达托霉素%合成基因簇%衍生物%系统生物学%合成生物学
達託黴素%閤成基因簇%衍生物%繫統生物學%閤成生物學
체탁매소%합성기인족%연생물%계통생물학%합성생물학
daptomycin%synthetic genetic cluster%derivative%system biology%synthetic biology
随着高致病耐药菌的不断出现,临床上对新抗生素的需求十分迫切。达托霉素作为环脂肽类抗生素的第一个产品对耐药菌有很好的杀菌效果,且制剂用药方便,毒副作用小,被公认为病原菌最后一道防线——万古霉素的最佳替代品。本文在介绍达托霉素的理化特征和抗菌活性、合成基因簇的研究成果的基础上,重点对达托霉素及其衍生物的研究状况进行了综述,对达托霉素的生产及其衍生物的开发进行了展望:结合系统生物学为已有的达托霉素产生菌进一步进行代谢工程改造提供指导;通过合成生物学使达托霉素衍生物成为新型抗生素。
隨著高緻病耐藥菌的不斷齣現,臨床上對新抗生素的需求十分迫切。達託黴素作為環脂肽類抗生素的第一箇產品對耐藥菌有很好的殺菌效果,且製劑用藥方便,毒副作用小,被公認為病原菌最後一道防線——萬古黴素的最佳替代品。本文在介紹達託黴素的理化特徵和抗菌活性、閤成基因簇的研究成果的基礎上,重點對達託黴素及其衍生物的研究狀況進行瞭綜述,對達託黴素的生產及其衍生物的開髮進行瞭展望:結閤繫統生物學為已有的達託黴素產生菌進一步進行代謝工程改造提供指導;通過閤成生物學使達託黴素衍生物成為新型抗生素。
수착고치병내약균적불단출현,림상상대신항생소적수구십분박절。체탁매소작위배지태류항생소적제일개산품대내약균유흔호적살균효과,차제제용약방편,독부작용소,피공인위병원균최후일도방선——만고매소적최가체대품。본문재개소체탁매소적이화특정화항균활성、합성기인족적연구성과적기출상,중점대체탁매소급기연생물적연구상황진행료종술,대체탁매소적생산급기연생물적개발진행료전망:결합계통생물학위이유적체탁매소산생균진일보진행대사공정개조제공지도;통과합성생물학사체탁매소연생물성위신형항생소。
With continuous appearance of highly pathogenic bacteria which are resistant to antibiotics,the need for new antibiotics becomes much pressing in clinical medicine.As the first production of cyclo-lipotpeptied antibiotics daptomycin has effective bactericidal effect to antibiotic resistant bacteria.Because of its convenience in preparation and treatment,as well as insignificant side effects,daptomycin is the perfect replacement of vancomycin recognized as the last line of defense to pathogen.On the basis of introducing physical and chemical characteristics,antimicrobial activity and research achievement of synthetic genetic cluster of daptomycin,this paper mainly summarizes research situation of daptomycin and its derivatives.And the paper also presents perspectives about production of daptomycin and development of its derivatives,including combining with system biology to provide guidance for daptomycin strains' further metabolic engineering improvement and utilizing synthetic biology to make derivatives of daptomycin new antibiotic.