化工进展
化工進展
화공진전
CHEMICAL INDUSTRY AND ENGINEERING PROGRESS
2012年
12期
2694-2701,2719
,共9页
多相催化%不对称氢化%手性催化剂%酒石酸%金鸡纳生物碱
多相催化%不對稱氫化%手性催化劑%酒石痠%金鷄納生物堿
다상최화%불대칭경화%수성최화제%주석산%금계납생물감
heterogeneous catalysis%enantioselective hydrogenation%chiral catalyst%tartaric acid%cinchona alkaloids
手性修饰金属催化剂是最具发展潜力的多相不对称催化剂之一。本文综述了近年来三个具有代表性的多相不对称氢化反应体系的研究进展,即酒石酸修饰镍催化剂催化β-酮酯不对称加氢体系、金鸡纳生物碱修饰铂催化剂催化α-酮酯不对称加氢体系以及金鸡纳生物碱修饰钯催化剂催化C=C和C=N双键不对称加氢体系。概述了催化体系的影响因素,探讨了酒石酸及金鸡纳生物碱修饰型催化剂的手性识别机理模型。指出开发高效催化剂,修正或提出手性识别机理模型仍是今后多相不对称催化氢化反应研究的方向。
手性脩飾金屬催化劑是最具髮展潛力的多相不對稱催化劑之一。本文綜述瞭近年來三箇具有代錶性的多相不對稱氫化反應體繫的研究進展,即酒石痠脩飾鎳催化劑催化β-酮酯不對稱加氫體繫、金鷄納生物堿脩飾鉑催化劑催化α-酮酯不對稱加氫體繫以及金鷄納生物堿脩飾鈀催化劑催化C=C和C=N雙鍵不對稱加氫體繫。概述瞭催化體繫的影響因素,探討瞭酒石痠及金鷄納生物堿脩飾型催化劑的手性識彆機理模型。指齣開髮高效催化劑,脩正或提齣手性識彆機理模型仍是今後多相不對稱催化氫化反應研究的方嚮。
수성수식금속최화제시최구발전잠력적다상불대칭최화제지일。본문종술료근년래삼개구유대표성적다상불대칭경화반응체계적연구진전,즉주석산수식얼최화제최화β-동지불대칭가경체계、금계납생물감수식박최화제최화α-동지불대칭가경체계이급금계납생물감수식파최화제최화C=C화C=N쌍건불대칭가경체계。개술료최화체계적영향인소,탐토료주석산급금계납생물감수식형최화제적수성식별궤리모형。지출개발고효최화제,수정혹제출수성식별궤리모형잉시금후다상불대칭최화경화반응연구적방향。
Chirally modified metal catalysts are one of most developed and promising heterogeneous enantioselective catalysts.The recent progress of the enantioselective hydrogenation of β-ketoesters on tartaric acid modified nickel catalysts,the enantioselective hydrogenation of α-ketoesters using cinchona alkaloid modified platinum,and the enantioselective hydrogenation of carbon-carbon and carbon-nitrogen double bonds using cinchona alkaloid modified palladium catalysts are summarized.The influential factors of the catalyst systems are briefly introduced,and the enantioselection mechanism in tartaric acid modified nickel catalysts and cinchona alkaloids modified platinum catalysts are also discussed.In addition,further research work in heterogeneous asymmetric hydrogenation should be focused on development of high efficiency catalysts and investigation of reaction mechanism.
