化工进展
化工進展
화공진전
CHEMICAL INDUSTRY AND ENGINEERING PROGRESS
2012年
10期
2288-2294
,共7页
郭辉%庄玉伟%王颖%曹健%郭晓战%张国宝
郭輝%莊玉偉%王穎%曹健%郭曉戰%張國寶
곽휘%장옥위%왕영%조건%곽효전%장국보
1,2,3,4-四氢喹啉类化合物%药物化学%染料%合成
1,2,3,4-四氫喹啉類化閤物%藥物化學%染料%閤成
1,2,3,4-사경규람류화합물%약물화학%염료%합성
1%2%3%4-tetrahydroquinoline derivatives%medicinal chemistry%dye%synthesis
1,2,3,4-四氢喹啉类化合物是治疗心血管病药物和染料的中间体。综述了1,2,3,4-四氢喹啉类化合物合成及应用的研究进展,分析比较了氢化反应、Diels-Alder反应、多步反应、多组分反应、多米诺反应等合成方法的优缺点,讨论了1,2,3,4-四氢喹啉类化合物在药物化学和染料合成领域的应用现状,并对其研究前景进行了展望：发展具有原子经济性合成方法及光学纯1,2,3,4-四氢喹啉类化合物的合成及应用。
1,2,3,4-四氫喹啉類化閤物是治療心血管病藥物和染料的中間體。綜述瞭1,2,3,4-四氫喹啉類化閤物閤成及應用的研究進展,分析比較瞭氫化反應、Diels-Alder反應、多步反應、多組分反應、多米諾反應等閤成方法的優缺點,討論瞭1,2,3,4-四氫喹啉類化閤物在藥物化學和染料閤成領域的應用現狀,併對其研究前景進行瞭展望：髮展具有原子經濟性閤成方法及光學純1,2,3,4-四氫喹啉類化閤物的閤成及應用。
1,2,3,4-사경규람류화합물시치료심혈관병약물화염료적중간체。종술료1,2,3,4-사경규람류화합물합성급응용적연구진전,분석비교료경화반응、Diels-Alder반응、다보반응、다조분반응、다미낙반응등합성방법적우결점,토론료1,2,3,4-사경규람류화합물재약물화학화염료합성영역적응용현상,병대기연구전경진행료전망：발전구유원자경제성합성방법급광학순1,2,3,4-사경규람류화합물적합성급응용。
1,2,3,4-tetrahydroquinoline derivatives are important intermediates of cardiovascular drugs and dye.The recent advances in the synthesis and application of 1,2,3,4-tetrahydroquinoline derivatives are reviewed in this paper.Different synthetic methods,including hydrogenation reaction,Diels-Alder reaction,multi-step reaction,multi-component reaction,and domino reaction,are compared,and the applications of 1,2,3,4-tetrahydroquinoline derivatives in medicinal chemistry and dye are also discussed.From the view of synthesis and practical applications,the research perspective of 1,2,3,4-tetrahydroquinoline derivatives is outlined in the end of this paper,which are the development of atom-economic methods and the synthesis and application of enantiomerically pure 1,2,3,4-tetrahydroquinoline derivatives.
