化工进展
化工進展
화공진전
CHEMICAL INDUSTRY AND ENGINEERING PROGRESS
2012年
4期
866-872,888
,共8页
高文亮%李林凤%张静静%黎学明%郑道敏%姚如杰%杨成威
高文亮%李林鳳%張靜靜%黎學明%鄭道敏%姚如傑%楊成威
고문량%리림봉%장정정%려학명%정도민%요여걸%양성위
蛋氨酸%海因水解%结晶%生产工艺
蛋氨痠%海因水解%結晶%生產工藝
단안산%해인수해%결정%생산공예
methionine%hydantoin hydrolysis%crystallization%production process
蛋氨酸被广泛应用于生物、医药、饲料、食品等诸多领域。针对全球蛋氨酸工业急剧发展这一现状,本文简要综述了近年来国内外蛋氨酸的生产工艺,包括生物酶拆分法、微生物发酵法和化学合成法,其中化学合成法主要有氨基内酯法、丙二酸酯法、固-液相转移催化法和海因法等,重点讨论了海因水解制备蛋氨酸及蛋氨酸结晶过程中的关键技术,并结合我国蛋氨酸生产的现状展望了蛋氨酸的发展前景:利用石油化工副产品,尽快建立起现代化蛋氨酸企业。
蛋氨痠被廣汎應用于生物、醫藥、飼料、食品等諸多領域。針對全毬蛋氨痠工業急劇髮展這一現狀,本文簡要綜述瞭近年來國內外蛋氨痠的生產工藝,包括生物酶拆分法、微生物髮酵法和化學閤成法,其中化學閤成法主要有氨基內酯法、丙二痠酯法、固-液相轉移催化法和海因法等,重點討論瞭海因水解製備蛋氨痠及蛋氨痠結晶過程中的關鍵技術,併結閤我國蛋氨痠生產的現狀展望瞭蛋氨痠的髮展前景:利用石油化工副產品,儘快建立起現代化蛋氨痠企業。
단안산피엄범응용우생물、의약、사료、식품등제다영역。침대전구단안산공업급극발전저일현상,본문간요종술료근년래국내외단안산적생산공예,포괄생물매탁분법、미생물발효법화화학합성법,기중화학합성법주요유안기내지법、병이산지법、고-액상전이최화법화해인법등,중점토론료해인수해제비단안산급단안산결정과정중적관건기술,병결합아국단안산생산적현상전망료단안산적발전전경:이용석유화공부산품,진쾌건립기현대화단안산기업。
Methionine has been used in many industrial fields,such as organism,medication,feedstuff and foodstuff,and shows a promising market demanding and a potential application prospect.This paper briefly reviews its domestic and foreign advance in production process,including enzymatic decomposition,microbial fermentation,and chemical synthesis.Chemical synthesis,including amino lactone method,malonic ester method,catalytic alkylation by solid-liquid phase transfer and hydantoin method,is emphasized,the key manufacture technique for hydantoin hydrolysis and methionine crystallization is especially intensively described.In the end,the development direction and application perspective in the domestic market are also prospected,which suggest that modern enterprise for methionine production should be built up as soon as possible using petrochemical byproducts.