CAJ | 학술논문

目的检测SLE患者的嗅觉功能,并探讨嗅觉功能受损与抗核糖体P蛋白抗体(ARPA)、病程及年龄的关系.方法采用康涅狄格州化学感受临床研究中心(CCCRC)检测法检测65例SLE患者和50名健康人的嗅觉功能;采用ELISA法检测SLE患者及健康对照组血清中的ARPA水平.采用t检验、单因素方差分析、LSD-t检验、Pearson相关分析、多元线性回归分析和x2检验进行统计分析.结果 ①活动组SLE患者CCCRC得分[(62±16)分]低于非活动SLE组[(80±13)分]及健康对照组[(83±12)分],差异均有统计学意义(F=26.52,P均＜0.01),非活动组和健康对照组之间差异无统计学意义(P=0.226).②在SLE患者中,ARPA阳性16例(阳性率25％),阴性49例(阴性率75％),ARPA阳性组和阴性组CCCRC得分差异有统计学意义[分别为(61±17)分,(74±16)分;t=2.681,P=0.009].③SLE患者CCCRC得分与ARPA血清水平呈线性相关关系(r=-0.327,P=0.008),与病程无明显相关性(r=0.141,P＞0.05).多元线性回归分析显示,年龄越大、ARPA水平越高,CCCRC得分越低.结论活动期SLE患者存在嗅觉功能障碍,年龄和ARPA与嗅觉障碍有一定的相关性.
목적 검측SLE환자적후각공능,병탐토후각공능수손여항핵당체P단백항체(ARPA)、병정급년령적관계.방법 채용강열적격주화학감수림상연구중심(CCCRC)검측법검측65례SLE환자화50명건강인적후각공능;채용ELISA법검측SLE환자급건강대조조혈청중적ARPA수평.채용t검험、단인소방차분석、LSD-t검험、Pearson상관분석、다원선성회귀분석화x2검험진행통계분석.결과 ①활동조SLE환자CCCRC득분[(62±16)분]저우비활동SLE조[(80±13)분]급건강대조조[(83±12)분],차이균유통계학의의(F=26.52,P균＜0.01),비활동조화건강대조조지간차이무통계학의의(P=0.226).②재SLE환자중,ARPA양성16례(양성솔25％),음성49례(음성솔75％),ARPA양성조화음성조CCCRC득분차이유통계학의의[분별위(61±17)분,(74±16)분;t=2.681,P=0.009].③SLE환자CCCRC득분여ARPA혈청수평정선성상관관계(r=-0.327,P=0.008),여병정무명현상관성(r=0.141,P＞0.05).다원선성회귀분석현시,년령월대、ARPA수평월고,CCCRC득분월저.결론 활동기SLE환자존재후각공능장애,년령화ARPA여후각장애유일정적상관성.
Objective To investigate the olfactory function in patients with systemic lupus erythematosus (SLE) and to explore factors that may influence it.Methods The Connecticut Chemosensory Clinical Research Center (CCCRC) test was carried out in SLE patients and healthy controls for olfactory function testing.ELISA method was used to detect anti-ribosomal P protein antibody in the serum.The statistical methods used in this study including t test,ANOVA,LSD-t test,Pearson correlation analysis,multiple linear regression analysis,andx2 test.Results ① The CCCRC scores of the active,inactive group and healthy controls were compared,the difference was statistical significant (F=26.52,P=0.01).CCCRC score in active SLE group (62±16) was lower than that of the inactive group (80±13) the and the normal control group (83±12) (P＜0.01),while there was no statistical significant difference between the inactive group and the normal controls (P=0.226).② CCCRC score was lower in 16 ARPA positive SLE patients (61±17) than 49 negative patients (74±16) (t=2.681,P=0.009).③ In addition,CCCRC score showed a negative correlation with ARPA serum concentration (r=-0.327,P=0.008).There was no significant correlation between CCCRC score and disease course (r=0.141,P＞0.05).④ Multiple linear regression analysis indicated that CCCRC score was associated with age and ARPA.Conclusion SLE patients have olfactory dysfunction and the dys-function is associated with age and ARPA.