CAJ | 학술논문

目的探讨网织红细胞参数在恶性肿瘤化疗前后的变化及临床意义.方法选择我院2013年1月至12月收治的36例需行化疗的恶性肿瘤患者为研究对象,使用Sysmex XT-4000i全自动血液分析仪对比观察其化疗前后网织红细胞参数的变化情况,分析其临床意义.结果患者在化疗后第7天时白细胞值(WBC)显著降低,到第14天时降到最低,差异具有统计学意义(P＜0.05),到第21天时,WBC开始回升;而网织红细胞百分数(RET％)以及未成熟网织红细胞指数(IRF)在化疗后第7天时降到最低,差异具有统计学意义(P＜0.05),在第14天时开始回升,到第21天时基本恢复到化疗前水平.结论网织红细胞参数是一个较为敏感的指标,可用来评价恶性肿瘤患者化疗前后骨髓造血功能的抑制情况,值得临床推广.
목적 탐토망직홍세포삼수재악성종류화료전후적변화급림상의의.방법 선택아원2013년1월지12월수치적36례수행화료적악성종류환자위연구대상,사용Sysmex XT-4000i전자동혈액분석의대비관찰기화료전후망직홍세포삼수적변화정황,분석기림상의의.결과 환자재화료후제7천시백세포치(WBC)현저강저,도제14천시강도최저,차이구유통계학의의(P＜0.05),도제21천시,WBC개시회승;이망직홍세포백분수(RET％)이급미성숙망직홍세포지수(IRF)재화료후제7천시강도최저,차이구유통계학의의(P＜0.05),재제14천시개시회승,도제21천시기본회복도화료전수평.결론 망직홍세포삼수시일개교위민감적지표,가용래평개악성종류환자화료전후골수조혈공능적억제정황,치득림상추엄.
Objective To investigate the variation and clinical significance of reticulocyte parameters before and after the chemotherapy for malignant tumor.Methods 36 patients,admitted to our hospital from January to December,2013,needing chemotherapy,were selected as study objects.Sysmex XT4000i automated hematology analyzer was used to observe the change of reticulocyte parameters before and after the chemotherapy.Results The WBC values were significantly lower on day 7 after the chemotherapy and decreased to a minimum on day 14,with a statistical difference (P ＜ 0.05).The WBC values bcgan to rise on day 21.The reticulocyte parameters and immature reticulocyte index decreased to a minimum on day 7,with statistical differences (P ＜ 0.05).The reticulocyte parameters and immature reticulocyte index began to rise on day 14,and recovered to the levcl before chemotherapy on day 21.Conclusions Reticulocyte parameters is a sensitive indicator for evaluating the inhibition of bone marrow function before and after the chemotherapy and is worth being clinically generalized.