CAJ | 학술논문

目的：介绍一种新型腰椎间融合器（cage）的设计理念和结构，对其进行生物力学评价。方法采用纳米羟基磷灰石和多聚氨基酸/硫酸钙共聚物材料研制的部分可吸收椎间融合器（PBIFC），在新鲜小牛L3/L4脊柱功能节段标本上测试自体植骨融合组、PBIFC组、纳米羟基磷灰石/聚酰胺66（n-HA/PA66）融合器组在前屈、后伸、侧屈、旋转状态下的活动角度值（ROM ）和最大抗压载荷和拔出力。结果各运动状态，髂骨组ROM值比其余两组大，差异有统计学意义（P＜0．05）；PBIFC组ROM 值较n-HA/PA66组大，但差异无统计意义（P＞0．05）。PBIFC组拔出力较髂骨组大，差异有统计学意义（P＜0．05）；PBIFC组较传统融合器组平均拔出力值小，但差异无统计意义（P＞0．05）。髂骨组的抗压载荷显著低于两椎间融合器组，差异有统计学意义（P＜0．05）；PBIFC组抗压缩载荷较n-HA/PA66组稍低，但差异无统计意义（P＞0．05）。结论 PBIFC具有良好的植入运动稳定性、抗拔出和抗压缩性能，能满足临床植入的生物力学要求。
목적：개소일충신형요추간융합기（cage）적설계이념화결구，대기진행생물역학평개。방법채용납미간기린회석화다취안기산/류산개공취물재료연제적부분가흡수추간융합기（PBIFC），재신선소우L3/L4척주공능절단표본상측시자체식골융합조、PBIFC조、납미간기린회석/취선알66（n-HA/PA66）융합기조재전굴、후신、측굴、선전상태하적활동각도치（ROM ）화최대항압재하화발출력。결과각운동상태，가골조ROM치비기여량조대，차이유통계학의의（P＜0．05）；PBIFC조ROM 치교n-HA/PA66조대，단차이무통계의의（P＞0．05）。PBIFC조발출력교가골조대，차이유통계학의의（P＜0．05）；PBIFC조교전통융합기조평균발출력치소，단차이무통계의의（P＞0．05）。가골조적항압재하현저저우량추간융합기조，차이유통계학의의（P＜0．05）；PBIFC조항압축재하교n-HA/PA66조초저，단차이무통계의의（P＞0．05）。결론 PBIFC구유량호적식입운동은정성、항발출화항압축성능，능만족림상식입적생물역학요구。
objective To introduce the design concept and structure of a new type of lumbar intervertebral fusion cage ,and to e-valuate its biomechanical properties .Method A partially bioasorbable interbody fusion cage(PBIFC) made of nano hydroxyapatite and poly amino acid /calcium sulfate copolymer materials was developed .Range of motion(ROM ) ,compressive load ,and pull-out test on flexion ,extension ,lateral bending ,and torsion moment on fresh calf L3/L4 specimens of functional spinal union were carried out of iliac bone group ,PBIFC group ,and nano hydroxyapatite/polyamide 66(nHA/PA66) group .Result Of each movement ,the ROM value of iliac bone group are higher than the other two groups ,the difference was statistically significant (P<0 .05) ,and the ROM value of nHA/PA66 group are higher than PBIFC group ,but no statistical difference(P>0 .05) .The pull-out strength of PB-IFC group are higher than iliac bone group ,and the difference was statistically significant (P<0 .05);The pull-out strength of PB-IFC group is lower than the traditional group ,but no statistical difference(P>0 .05) .The compressive load of iliac bone group was lower than that of two cage group ,the difference was statistically significant (P<0 .05) .The compressive load of PBIFC group is slightly lower than the traditional group ,but no statistical difference(P>0 .05) .Conclusion With good implant stability ,pull-out resistance ,and compression resistance performance ,PBIFC can meet the biomechanics requirements of clinical implant .