CAJ | 학술논문

目的观察胃旁路术(GBP)对Ⅱ型糖尿病大鼠血糖及血清胰高血糖素样肽-1(GLP-1)的影响.方法对80只雄性SD大鼠腹腔注射链脲佐菌素建立2型糖尿病模型.将建模成功的大鼠分成手术组18只(O组)；假手术组15只(S组)；饮食控制组15只(F组)；对照组15只(C组).检测术前及术后1、2、4、8周的体质量、空腹血糖、空腹血浆胰岛素水平、空腹血清GLP-1浓度.结果 (1)O组术后空腹血糖第8周降至(8.2±2.4)mmol/L,与术前比较差异有统计学意义(P＜0.05).(2)O组术后空腹血浆胰岛素8周后从术前(29.1±5.1)mU/L升至(72.5 ±7.4) mU/L(P ＜0.05).(3)O组术后GLP-1明显升高,到第8周上升至(23.26±2.19) pmol/L(P＜0.05).结论胃旁路手术可以有效降低2型糖尿病大鼠的血糖并引起GLP-1的高分泌,其血糖下降与限制饮食及体质量下降无明显相关.
목적 관찰위방로술(GBP)대Ⅱ형당뇨병대서혈당급혈청이고혈당소양태-1(GLP-1)적영향.방법 대80지웅성SD대서복강주사련뇨좌균소건립2형당뇨병모형.장건모성공적대서분성수술조18지(O조)；가수술조15지(S조)；음식공제조15지(F조)；대조조15지(C조).검측술전급술후1、2、4、8주적체질량、공복혈당、공복혈장이도소수평、공복혈청GLP-1농도.결과 (1)O조술후공복혈당제8주강지(8.2±2.4)mmol/L,여술전비교차이유통계학의의(P＜0.05).(2)O조술후공복혈장이도소8주후종술전(29.1±5.1)mU/L승지(72.5 ±7.4) mU/L(P ＜0.05).(3)O조술후GLP-1명현승고,도제8주상승지(23.26±2.19) pmol/L(P＜0.05).결론 위방로수술가이유효강저2형당뇨병대서적혈당병인기GLP-1적고분비,기혈당하강여한제음식급체질량하강무명현상관.
Objective To investigate the effect of gastric bypass (GBP) on rats with type 2 diabetes induced by streptozotocin (STZ) injection and the action mechanisms involved.Methods Twenty rats were divided into 4 groups:operation group (group O,n =18),sham operation group (group S,n =15),food control group (group F,n =15) and control group (group C,n =15).Weight,fasting blood glucose (FBG),fasting plasma insulin (FPI) and glucagon-like peptide-1 (GLP-1) were measured 1,2,4 and 8 weeks after operation.Results (1) FBG in O group 8 weeks after operation was reduced to (8.2 ±2.4) mmol/L (P ＜ 0.05) ; (2) FPI in O group was increased after operation and reached (72.5 ±7.4) mU/L at week 8 was compared with that before operation [(29.1 ± 5.1) mU/L] ; (3) GLP-1 in O Group at 8th week after operation was increased to (23.26 ± 2.19) pmoL/L(P ＜0.05).Conclusion GBP was an effective therapy to control blood glucose in type 2 diabetic rats and lead to high secretion of GLP-1.There is no significant relation between decreased blood glucose in type 2 diabetic rats with restricted diet and weight loss after GBP.