CAJ | 학술논문

目的探讨黄芩苷对创伤性休克患者血清炎性因子和氧自由基代谢的影响.方法38例创伤性休克的患者入院后予黄芩苷200 mg静脉注射,测定用药前及用药后1h静脉血TNF-α、IL-6、IL-8、丙二醛(MDA)的含量以及超氧化物歧化酶(SOD)活力.结果治疗前后比较,患者血清TNF-α、IL-6、IL-8、MDA含量均明显下降(t=7.32、6.12、20.21、16.10,均P＜0.05),而SOD活力明显增加(t=1.69,P＜0.01).结论黄芩苷可抑制创伤性休克患者血清炎性因子生成和释放,减轻氧化应激损伤.
목적탐토황금감대창상성휴극환자혈청염성인자화양자유기대사적영향.방법38례창상성휴극적환자입원후여황금감200 mg정맥주사,측정용약전급용약후1h정맥혈TNF-α、IL-6、IL-8、병이철(MDA)적함량이급초양화물기화매(SOD)활력.결과치료전후비교,환자혈청TNF-α、IL-6、IL-8、MDA함량균명현하강(t=7.32、6.12、20.21、16.10,균P＜0.05),이SOD활력명현증가(t=1.69,P＜0.01).결론황금감가억제창상성휴극환자혈청염성인자생성화석방,감경양화응격손상.
Objective To investigate the effect of baicalin on inflammatory factors and oxygen free radical metabolism in patients with traumatic shock.Methods 38 patients with traumatic shock were treated with baicalin 200mg intravenous injection when admitted to hospital.Before and 1 h after treatment,TNF-α,IL-6,IL-8,MDA and SOD were measured in blood.Results Compared with before treatment,TNF-,IL-6,IL-8,and MDA levels were decreased after treatment (t =7.32,6.12,20.21,16.10,all P ＜ 0.05),while SOD activity was significantly increased (t =1.69,P ＜ 0.01).Conclusion Baicalin could inhibit the production and release of inflammatory factors TNF-α,IL-6,IL-8 in patients with traumatic shock,reduce the damage of oxygen free radicals to the cells.Early treatment with baicalin had protective effect on patients with traumatic shock.