中华脑科疾病与康复杂志（电子版）
中華腦科疾病與康複雜誌（電子版）
중화뇌과질병여강복잡지（전자판）
CHINESE JOURNAL OF BRAIN DI8SEASES AND REHABILITATIN(ELECTRONIC EDITION)
2014年
5期
40-43
,共4页
癫痫%认知障碍%抗惊厥药%影响
癲癇%認知障礙%抗驚厥藥%影響
전간%인지장애%항량궐약%영향
Epilepsy%Cognition disorders%Anticonvulsants%Impact
癫痫是小儿时期常见的神经系统慢性疾病。有研究报道大多数癫痫患儿的认知发育正常，但从总体来看，癫痫患儿的认知水平低于正常儿童。癫痫的认知功能损害主要表现为对外部信息的整合能力下降，其与癫痫发作类型、癫痫发病年龄、癫痫病程、癫痫发作频率、癫痫持续时间、病灶部位、癫痫的基础疾病/病因及社会心理等因素相关。一直以来，癫痫治疗最重要的目的都是控制癫痫发作，目前大量实验研究表明，新型抗癫痫药物通过神经传递、离子通道、第二信使以及其他环节进行调节控制癫痫发作，从而改善癫痫的认知损害，提高患者的生活质量，但也在某些方面影响患儿的认知功能。
癲癇是小兒時期常見的神經繫統慢性疾病。有研究報道大多數癲癇患兒的認知髮育正常，但從總體來看，癲癇患兒的認知水平低于正常兒童。癲癇的認知功能損害主要錶現為對外部信息的整閤能力下降，其與癲癇髮作類型、癲癇髮病年齡、癲癇病程、癲癇髮作頻率、癲癇持續時間、病竈部位、癲癇的基礎疾病/病因及社會心理等因素相關。一直以來，癲癇治療最重要的目的都是控製癲癇髮作，目前大量實驗研究錶明，新型抗癲癇藥物通過神經傳遞、離子通道、第二信使以及其他環節進行調節控製癲癇髮作，從而改善癲癇的認知損害，提高患者的生活質量，但也在某些方麵影響患兒的認知功能。
전간시소인시기상견적신경계통만성질병。유연구보도대다수전간환인적인지발육정상，단종총체래간，전간환인적인지수평저우정상인동。전간적인지공능손해주요표현위대외부신식적정합능력하강，기여전간발작류형、전간발병년령、전간병정、전간발작빈솔、전간지속시간、병조부위、전간적기출질병/병인급사회심리등인소상관。일직이래，전간치료최중요적목적도시공제전간발작，목전대량실험연구표명，신형항전간약물통과신경전체、리자통도、제이신사이급기타배절진행조절공제전간발작，종이개선전간적인지손해，제고환자적생활질량，단야재모사방면영향환인적인지공능。
Epilepsy is a chronic disease of the nervous system which is commonly contracted by children.The cognitive abilities of these affected children are mostly in an average level ,but still lower as a whole than those of the normal children .The cognitive impairment caused by epilepsy is mainly reflected in the children′s decreasing ability of integrating the external information .The extent of the damage caused by this impairment to the integrating ability can be decided by the epilepsy′s seizure type ,age of onset ,affection process,seizure frequency,disease duration,lesion focus,basic diseases/causes that may lead to epilepsy, social psychology,and so on.For a long time,the most important objective of epilepsy treatments has been to take control of epilepsy seizures .A great deal of current experiments and researches has demonstrated that the theory of newly-invented anti-epilepsy medicines is to contain epilepsy seizures through neurotransmission ,ion channels,second messenger and other links .In this way,the cognitive impairment is relieved and the patient′s life quality improved .However , one disadvantage of this treatment is its harmfulness to the children′s cognitive functions in some ways.Antiepileptic drugs through the neurotransmitter ,ion channels,the second messenger ,and other links to adjust control seizures .Thus reduce cognitive impairment of epilepsy , improve the quality of life of patients ,but also affect children′s cognitive function in some ways .
