CAJ | 학술논문

目的：探索成年期甲状腺功能异常对患者空间记忆和物体记忆的影响。方法选择2013年3至11月在安徽医科大学第一附属医院内分泌科门诊就诊的甲状腺功能异常的患者，按甲状腺素水平将患者分为甲状腺功能亢进组（甲亢组，42例）和甲状腺功能减退组（甲减组，16例），并按是否存在甲状腺相关抗体分为抗体阳性和抗体阴性亚组，收集患者背景资料，采用九盒迷宫实验检测空间记忆和物体记忆，以27例健康体检者为对照。采用SPSS 17.0进行统计学分析，组间差异比较采用t检验、单因素方差分析、秩和检验或χ2检验。结果与对照组相比，甲亢患者的空间参考（z＝2.407，P＝0.016）和物体再认（z＝7.553，P＜0.001）错误分值和甲减患者的物体再认（z＝6.221，P＜0.001）错误分值显著增高；甲亢抗体阳性者的空间参考（z＝3.695，P＜0.001）、空间工作（z＝2.693， P＝0.007）和物体再认（ z＝6.415， P＜0.001）及甲减抗体阳性者的空间工作（ z＝2.574， P＝0.010）、物体再认（ z＝5.655，P＜0.001）错误分值显著增加，甲亢和甲减抗体阴性者的物体再认错误分值也显著增加（ z＝6.699、5.422，均P＜0.001）。结论甲状腺功能障碍患者（尤其是甲状腺相关抗体阳性者）存在一定程度的认知功能损害，自身免疫因素可能参与其中。
목적：탐색성년기갑상선공능이상대환자공간기억화물체기억적영향。방법선택2013년3지11월재안휘의과대학제일부속의원내분비과문진취진적갑상선공능이상적환자，안갑상선소수평장환자분위갑상선공능항진조（갑항조，42례）화갑상선공능감퇴조（갑감조，16례），병안시부존재갑상선상관항체분위항체양성화항체음성아조，수집환자배경자료，채용구합미궁실험검측공간기억화물체기억，이27례건강체검자위대조。채용SPSS 17.0진행통계학분석，조간차이비교채용t검험、단인소방차분석、질화검험혹χ2검험。결과여대조조상비，갑항환자적공간삼고（z＝2.407，P＝0.016）화물체재인（z＝7.553，P＜0.001）착오분치화갑감환자적물체재인（z＝6.221，P＜0.001）착오분치현저증고；갑항항체양성자적공간삼고（z＝3.695，P＜0.001）、공간공작（z＝2.693， P＝0.007）화물체재인（ z＝6.415， P＜0.001）급갑감항체양성자적공간공작（ z＝2.574， P＝0.010）、물체재인（ z＝5.655，P＜0.001）착오분치현저증가，갑항화갑감항체음성자적물체재인착오분치야현저증가（ z＝6.699、5.422，균P＜0.001）。결론갑상선공능장애환자（우기시갑상선상관항체양성자）존재일정정도적인지공능손해，자신면역인소가능삼여기중。
Objective To explore the effects of thyroid dysfunction on spatial and object memory in the adult patients .Methods Patients with thyroid dysfunction were recruited from the Department of Endocrinology of the First Hospital of Anhui Medical University from March 2013 to November 2013 . According to thyroid levels,patients were divided into hyperthyroidism group (42 cases)and hypothyroidism group(16 cases),and moreover they were divided into antibody positive and antibody negative subgroups according to whether they had thyroid-related antibodies .After the patients′background information was collected ,nine-box maze was used to assess their spatial and object memory .Normal individuals were enrolled as the controls(27 cases).Statistical analysis was performed by using SPSS 17.0,and t test,ANOVA,rank test or χ2 test were used to reveal any significant difference between groups .Results Compared to the controls,the hyperthyroidism patients had higher error scores in the spatial reference ( z=2.407 ,P=0.016 ) and object memory(z=7.553,P<0.001),and so did the hyperthyroidism patients in the object memory (z=6.221 , P<0.001 ) .In the antibody positive subgroups , the hyperthyroidism patients showed more error scores in the spatial reference ( z =3.695 , P<0.001 ) , spatial working ( z=2.693 , P=0.007 ) and object memories(z=6.415,P<0.001)than the controls,and it was similar to hyperthyroidism patients in spatial working(z=2.574, P =0.010 ) and object memories ( z =5.655, P <0.001 ).In the antibody negative subgroups ,the hyperthyroidism and hyperthyroidism patients only displayed more error scores in the object memory than the controls ( z =6.699 , 5.422 , all Ps <0.001 ) .Conclusion The patients with thyroid dysfunction ,especially for the antibody positive individuals ,have a certain degree of memory impairment ,and autoimmune factor may be a cause involved in their cognitive damage .