CAJ | 학술논문

近年来研究证实，人内源性逆转录病毒（ HERV）中长末端重复序列（ LTR）和囊膜蛋白基因（ env）与基因异常表达关系密切。本文阐述了HERV国内外研究现状与发展动态。从生物信息学角度对LTR中启动子、多聚腺苷化（ PolyA）信号和增强子等顺式作用元件以及env中的免疫抑制区（ ISD）进行了重点分析。指出上述元件和潜在功能区在基因的异常表达和囊膜蛋白的免疫抑制中起关键作用，必将成为HERV与基因异常表达关系研究的热点与趋势。通过此类研究，以期为癌症疾病的早期诊断和治疗靶位点的选择奠定理论基础。
근년래연구증실，인내원성역전록병독（ HERV）중장말단중복서렬（ LTR）화낭막단백기인（ env）여기인이상표체관계밀절。본문천술료HERV국내외연구현상여발전동태。종생물신식학각도대LTR중계동자、다취선감화（ PolyA）신호화증강자등순식작용원건이급env중적면역억제구（ ISD）진행료중점분석。지출상술원건화잠재공능구재기인적이상표체화낭막단백적면역억제중기관건작용，필장성위HERV여기인이상표체관계연구적열점여추세。통과차류연구，이기위암증질병적조기진단화치료파위점적선택전정이론기출。
Recent studies have confirmed that long terminal repeats ( LTR) and the envelope gene ( env) of human endogenous retroviruses ( HERV) are closely related to aberrant gene expression. In this paper, the situations and development trends of domestic and foreign research on HERV were elaborated. The promoter, polyadenylation ( PolyA) signal, enhancer and other cis-acting elements of LTR as well as immunosuppressive domain ( ISD) of env in HERV were analyzed in the perspective of bioinformatics. It was suggested that the elements and potential functional domain, which play important roles in the abnormal gene expression and immunosuppression of envelope proteins, will become the focuses and trends of future research on the relationship between HERV and abnormal gene expression. It is hoped that these studies will be helpful to theoretical foundation for early diagnosis and selection of treatment target site of cancer.