CAJ | 학술논문

目的：研究奥美拉唑杂质：2-[（5-甲氧基-1 H-苯并咪唑-2-亚磺酰基）甲基]-3，5-二甲基-4-羟基吡啶的合成方法。方法以2-氯甲基-4-甲氧基-3，5-二甲基吡啶盐酸盐（CMML）为原料，通过脱甲基、缩合、氧化三步反应制得2-[（5-甲氧基-1 H-苯并咪唑-2-亚磺酰基）甲基]-3，5]二甲基-4-羟基吡啶。结果合成的目标化合物经核磁共振氢谱、核磁共振碳谱及质谱确证。结论该合成通过三步得到目标化合物，收率约为23％。
목적：연구오미랍서잡질：2-[（5-갑양기-1 H-분병미서-2-아광선기）갑기]-3，5-이갑기-4-간기필정적합성방법。방법이2-록갑기-4-갑양기-3，5-이갑기필정염산염（CMML）위원료，통과탈갑기、축합、양화삼보반응제득2-[（5-갑양기-1 H-분병미서-2-아광선기）갑기]-3，5]이갑기-4-간기필정。결과합성적목표화합물경핵자공진경보、핵자공진탄보급질보학증。결론해합성통과삼보득도목표화합물，수솔약위23％。
Objective To synthesize omeprazole impurity :2-[(5-methoxy-1 H-benzimidazole-2-sulfinyl)methyl]-3 ,5-dimethyl-4-hy-droxy-pyridine .Method 2-[(5-methoxy-1 H-benzimidazole-2-sulfinyl)methyl]-3 ,5-dimethyl-4-hydroxyl-pyridine was synthesized from 2-chloromethyl-4-methoxy-3 ,5-lutidine hydrochloride(CMML) by three-step reactions of demethylation ,condensation ,and oxidation .Result The structure of the target compound was confirmed by 1 H NMR ,13C NMR ,and MS .Conclusion The target compound was synthesized via three-step reactions with an overall yield about 23% .