CAJ | 학술논문

深部脑刺激可以有效治疗帕金森病、癫痫、抑郁等疾病。深部脑刺激电极是深部脑刺激系统中的重要组成部分，传统的四触点电极由于通道少，触点面积大，分辨率低，容易刺激不必要的区域从而引起副作用。为提高深部脑刺激的分辨率和精度，设计了一种具有24个触点的深部脑刺激电极，并利用微机电系统制作技术制作出柔性电极。该柔性电极基底材料为生物相容性良好的聚一氯对二甲苯（Parylene C），导电材料为金。电极触点和焊点均为285μm×1500μm ，连接焊点和触点的连接线宽为50μm 。初步电学测试表明，电极具有良好的低阻抗电学性能。使用多触点电极可减小触点尺寸，提高刺激的分辨率，改善脑刺激电极在临床中的治疗效果。
심부뇌자격가이유효치료파금삼병、전간、억욱등질병。심부뇌자격전겁시심부뇌자격계통중적중요조성부분，전통적사촉점전겁유우통도소，촉점면적대，분변솔저，용역자격불필요적구역종이인기부작용。위제고심부뇌자격적분변솔화정도，설계료일충구유24개촉점적심부뇌자격전겁，병이용미궤전계통제작기술제작출유성전겁。해유성전겁기저재료위생물상용성량호적취일록대이갑분（Parylene C），도전재료위금。전겁촉점화한점균위285μm×1500μm ，련접한점화촉점적련접선관위50μm 。초보전학측시표명，전겁구유량호적저조항전학성능。사용다촉점전겁가감소촉점척촌，제고자격적분변솔，개선뇌자격전겁재림상중적치료효과。
Deep brain stimulation (DBS) is effective for treating some diseases, such as epilepsy, Parkinson's disease or depression. DBS electrode is a key part of a DBS system. The current DBS electrode has four large contacts, and the stimulation resolution is low and the stimulation to unnecessary area of brain tissue may cause side effects. To improve the resolution and precision of the deep brain stimulation, a flexible electrode with multi- contact was designed and produced through a Micro- Electro-Mechanical Systems (MEMS) fabrication method. The new electrode consisted of 24 small contacts. Each electrode contact is 285μm í1 500μm. The micro machining techniques were applied for the electrode fabrication using biocompatible materials Parylene C as the substrate and Au as electrode material respectively. The characteristics of the electrode were physically tested. The electrode has a smooth surface, distinct outline and good electrical properties with low impedance. The MEMS technology is suitable for the deep brain stimulation electrode production. This research would provide a basis for developing better 3- D deep brain stimulation strategy.