CAJ | 학술논문

目的：评价第二代双源CT双能量心肌灌注“一站式”扫描得到的猪急性心肌梗死模型心肌灌注图像及冠状动脉图像的可行性和准确性。方法5只猪行介入明胶海绵栓塞法建立猪急性心肌梗死模型。分别于造模前20 min及造模后24～48 h行“一站式”扫描和冠状动脉造影。检查结束后立即取出心脏多点取活检行苏木素-伊红（HE）染色，然后将心脏切成薄片行氯化三苯基四氮唑（TTC）染色。以冠状动脉造影及病理染色为金标准分别评价第二代双源CT双能量心肌灌注“一站式”扫描重建得到猪急性心肌梗死模型的冠状动脉图像及心肌灌注图像的敏感性、特异性。以Kappa检验分析结果的一致性。结果与病理金标准对比，“一站式”扫描得到心肌灌注碘图像的敏感性、特异性分别为93％、91％，Kappa值为0.82；与冠状动脉造影金标准对比，“一站式”扫描得到冠状动脉图像的敏感性、特异性分别为93％、81％，Kappa值为0.71。结论第二代双源CT双能量心肌灌注“一站式”扫描可以准确得到猪急性心肌梗死模型的冠状动脉图像及心肌灌注图像。
목적：평개제이대쌍원CT쌍능량심기관주“일참식”소묘득도적저급성심기경사모형심기관주도상급관상동맥도상적가행성화준학성。방법5지저행개입명효해면전새법건립저급성심기경사모형。분별우조모전20 min급조모후24～48 h행“일참식”소묘화관상동맥조영。검사결속후립즉취출심장다점취활검행소목소-이홍（HE）염색，연후장심장절성박편행록화삼분기사담서（TTC）염색。이관상동맥조영급병리염색위금표준분별평개제이대쌍원CT쌍능량심기관주“일참식”소묘중건득도저급성심기경사모형적관상동맥도상급심기관주도상적민감성、특이성。이Kappa검험분석결과적일치성。결과여병리금표준대비，“일참식”소묘득도심기관주전도상적민감성、특이성분별위93％、91％，Kappa치위0.82；여관상동맥조영금표준대비，“일참식”소묘득도관상동맥도상적민감성、특이성분별위93％、81％，Kappa치위0.71。결론제이대쌍원CT쌍능량심기관주“일참식”소묘가이준학득도저급성심기경사모형적관상동맥도상급심기관주도상。
Objective To evaluated the feasibility and accuracy of obtaining the myocardial perfusion image and coronary artery image of pig models of acute myocardial infarction by the second generation dual-source CT dual-energy myocardial perfusion "one-stop" scanning. Methods The pig models of acute myocardial infarction was established by using the interventional gelatin sponge embolism method on 5 pigs. The myocardial perfusion scanning and coronary angiography were respectively used 20 min before and 24-48 h after modeling. The heart were taken out immediately after the inspection for multiple punch biopsy and HE staining, then the heart was sliced for triphenyltetrazolium chloride (TTC) staining. According to the gold standard of coronary angiography and pathological staining, the sensibility and speciifcity of the coronary artery image of acute myocardial infarction of pig reconstructed by myocardial perfusion scanning and the myocardial perfusion image were respectively evaluated, and the consistency of the results was veriifed by Kappa test. Results Compared with the pathologic gold standard, the sensitivity, speciifcity, of myocardial perfusion iodine image obtained by myocardial perfusion scanning were 93%, 91%; and Kappa value was 0.68. Compared with the coronary angiography gold standard, the sensitivity and speciifcity of coronary artery image obtained by myocardial perfusion scanning were 93%, 81%, and Kappa value was 0.71. Conclusions The second generation dual-source CT dual-energy myocardial perfusion"one-stop"scanning can accurately get the coronary artery and myocardial perfusion images of the pig models of acute myocardial infarction.