中国病理生理杂志
中國病理生理雜誌
중국병리생리잡지
CHINESE JOURNAL OF PATHOPHYSIOLOGY
2014年
6期
1136-1140
,共5页
间歇性低氧%氧化性应激%心室重塑%细胞凋亡
間歇性低氧%氧化性應激%心室重塑%細胞凋亡
간헐성저양%양화성응격%심실중소%세포조망
Intermittent hypoxia%Oxidative stress%Ventricular remodeling%Apoptosis
Intermittent hypoxia (IH) is a direct consequence of obstructive sleep apnea syndrome (OSAS), which results in left ventricular dysfunction , remodeling and myocardial cell injury .Understanding the mechanisms of OSAS is important for us to prevent and treat the cardiovascular complications in the clinical practices .We summarize the effects of IH on left ventricular function , and analyze the mechanisms at the cellular and molecular levels , including oxidative stress, ion exchangers and inflammation .In addition, the effects of endothelin-1 and hypercapnia on IH-induced cardiac injury are discussed .
