CAJ | 학술논문

目的：评价中药联合肝动脉导管化疗栓塞（TACE）后序贯射频消融（RFA）治疗大肝癌的疗效。方法72例（95个病灶）大肝癌患者（肿瘤直径5.1~14.5 cm），TACE 治疗后1周行 RFA治疗，24 h CT 评价，如有漏空现象，给予 RFA 1~2次补充治疗，最后一次 RFA 治疗后1个月再次行TACE 巩固治疗。术后所有患者均服用中药健脾化痰方。随访观察治疗效果、并发症和患者生存时间。结果 RFA 后完全缓解36例，部分缓解22例，病变进展14例。并发症7例（9.72%），包括电极片灼伤皮肤2例，气胸3例，腹腔出血2例。大肝癌 TACE 序贯 RFA 治疗后6个月、1、2、3年生存率分别为97.2%（70例）、73.6%（53例）、47.2%（34例）、33.3%（24例）。结论中药联合 TACE 后序贯RFA 是治疗大肝癌的一种有效治疗模式。
목적：평개중약연합간동맥도관화료전새（TACE）후서관사빈소융（RFA）치료대간암적료효。방법72례（95개병조）대간암환자（종류직경5.1~14.5 cm），TACE 치료후1주행 RFA치료，24 h CT 평개，여유루공현상，급여 RFA 1~2차보충치료，최후일차 RFA 치료후1개월재차행TACE 공고치료。술후소유환자균복용중약건비화담방。수방관찰치료효과、병발증화환자생존시간。결과 RFA 후완전완해36례，부분완해22례，병변진전14례。병발증7례（9.72%），포괄전겁편작상피부2례，기흉3례，복강출혈2례。대간암 TACE 서관 RFA 치료후6개월、1、2、3년생존솔분별위97.2%（70례）、73.6%（53례）、47.2%（34례）、33.3%（24례）。결론중약연합 TACE 후서관RFA 시치료대간암적일충유효치료모식。
Objective To evaluate the efficacy on large hepatocellular carcinoma(HCC)treated with Chinese medicines combined with radiofrequency ablation(RFA)after transcatheter arterial chemoemboliza-tion(TACE). Methods Seventy - two cases of large HHC had 95 foci(5. 1 ~ 14. 5 cm in diameter). RFA was applied after TACE. CT assessment was given in 24 h. RFA for one or twice were supplemented if leaka-ges were discovered. TACE was consolidated after the last RFA in one month. Results Thirty - six cases were completed ablated after RFA,22 cases basically ablated and 14 cases partially ablated. Seven cases (9. 72% )presented complications,including 2 cases of skin burns,3 cases of pneumothorax and 2 cases of abdominal hemorrhage. The survival rates were 97. 2%(70 cases),73. 6%(53 cases),47. 2%(34 cases)and 33. 3%(24 cases)in 6 months,1,2 and 3 years after RFA after TACE separately. Conclusion Chinese medi-cines combined with RFA after TACE is the effective therapeutic program for the treatment of large HCC.