CAJ | 학술논문

目的：探讨成功实行介入封堵治疗的左向右分流先天性心脏病即房间隔缺损在封堵前后即刻、随访期间肺动脉压力的变化规律。方法500例成功施行介入治疗的患者，经导管测定术前及封堵后即刻肺动脉压力，并对肺动脉压力在介入治疗前后进行对比研究。结果①正常/轻度肺动脉高压组：PASP、PAMP在封堵即刻后均轻度升高，前者升高有统计学差异（P<0.05）。②中度肺高压组：PASP和PAMP在封堵即刻后均明显降低（P<0.05）。结论①PH是ASD常见、且严重的并发症，肺动脉压力是其手术时机选择、疗效判断和预后的重要指标。监测肺动脉压力变化，探讨其变化规律对合并PH的ASD的诊断和治疗均具有重要的临床意义。②用肺动脉频谱法可以较准确地估测肺动脉压力，其对于PH的ASD具有重要诊断价值。③经导管封堵治疗合并PH的ASD是安全、有效的，介入治疗能明显降低中、重度肺动脉高压。
목적：탐토성공실행개입봉도치료적좌향우분류선천성심장병즉방간격결손재봉도전후즉각、수방기간폐동맥압력적변화규률。방법500례성공시행개입치료적환자，경도관측정술전급봉도후즉각폐동맥압력，병대폐동맥압력재개입치료전후진행대비연구。결과①정상/경도폐동맥고압조：PASP、PAMP재봉도즉각후균경도승고，전자승고유통계학차이（P<0.05）。②중도폐고압조：PASP화PAMP재봉도즉각후균명현강저（P<0.05）。결론①PH시ASD상견、차엄중적병발증，폐동맥압력시기수술시궤선택、료효판단화예후적중요지표。감측폐동맥압력변화，탐토기변화규률대합병PH적ASD적진단화치료균구유중요적림상의의。②용폐동맥빈보법가이교준학지고측폐동맥압력，기대우PH적ASD구유중요진단개치。③경도관봉도치료합병PH적ASD시안전、유효적，개입치료능명현강저중、중도폐동맥고압。
ObjectiveTo compare the changes of pulmonary artery pressure (systolic pulmonary pressure, PASP mean pulmonary pressure,PAMP) before and after transcatheter occlution with congenital heart disease with atrial septal defect (ASD)and during the fol ow-up. Method 500 patients underwent transcatheter closure of congenital heart disease with ASD,were involved in this study. The paraments of pulmonary artery pressure including PASP and PAMP were evaluated with cardiac catheter before and after procedures. Result ①In normal and mild group,systolic pulmonary pressure increased immediately after the operation (P<0.05). ②In moderate group, PASP and PAMP decreased immediately after the operation (P<0.05). Conclusion①The pulmonary pulmonary pressure by Doppler echocardiography and cardiac catheter was relate significantly in the patients with ASD.Pulmonary flow index can be used to evaluate the pulmonary the pulmonary pressure and the method was accurate.②Transcatheter closure of ASD with severe pulmonary hypertension by using closure was safe and ef ective.③transcatheter closure treatment PH merger of ASD is safe, ef ective Interventional treatment of can significantly reduce moderate to severe pulmonary hypertension.