CAJ | 학술논문

目的：探讨血液灌流（HP）联合血液透析（HD）对尿毒症透析患者同型半胱氨酸（Hcy）及超敏C反应蛋白、肿瘤坏死因子α等炎症因子的影响。方法选择尿毒症透析患者50例，分为单纯血液透析组（HD组）和血液灌流联合血液透析组（HP+HD组），每组25例，检测治疗前和治疗8w后血清 Hcy及 CRP、TNF-α的水平，同时测定治疗前后血红蛋白的水平。结果 HP+HD组治疗8w后Hcy及CRP、TNF-α的水平均低于HD组治疗后，差异具有统计学异议（P<0.01），HP+HD组治疗8w后血红蛋白较治疗前升高，差异具有统计学异议（P<0.01）。结论 HP联合HD治疗尿毒症患者可有效降低 Hcy水平，并改善微炎症状态，改善贫血。
목적：탐토혈액관류（HP）연합혈액투석（HD）대뇨독증투석환자동형반광안산（Hcy）급초민C반응단백、종류배사인자α등염증인자적영향。방법선택뇨독증투석환자50례，분위단순혈액투석조（HD조）화혈액관류연합혈액투석조（HP+HD조），매조25례，검측치료전화치료8w후혈청 Hcy급 CRP、TNF-α적수평，동시측정치료전후혈홍단백적수평。결과 HP+HD조치료8w후Hcy급CRP、TNF-α적수평균저우HD조치료후，차이구유통계학이의（P<0.01），HP+HD조치료8w후혈홍단백교치료전승고，차이구유통계학이의（P<0.01）。결론 HP연합HD치료뇨독증환자가유효강저 Hcy수평，병개선미염증상태，개선빈혈。
Objective To evaluate the blood perfusion (HP) combined hemodialysis (HD) in patients with uremia hemodialysis homocysteine (Hcy) and al ergic inflammation, such as c-reactive protein and tumor necrosis factor alpha factor influence. Methods 50 patients with uremia hemodialysis, divided into pure hemodialysis (HD) and blood perfusion combined hemodialysis group (HP+HD group), 25 cases in each group, test before and after 8 weeks treatment serum Hcy and CRP, the level of TNF alpha, at the same time to determine the level of hemoglobin before and after the treatment. Results HP+HD group 8 weeks after treatment Hcy and CRP, the level of TNF alpha were lower than that of HD group after treatment, the dif erence statistical y discrepancy (P<0.01), the HP+HD group 8 weeks after treatment hemoglobin was higher, the dif erence statistical y discrepancy (P<0.01). Conclusion HP with HD therapy uremia patients can ef ectively reduce the Hcy level, and improve the inflammatory state, improve anemia.