CAJ | 학술논문

目的：探讨高压氧联合多沙唑嗪治疗高原条件下Ⅲ型前列腺炎的疗效和机制。方法将94例Ⅲ型前列腺炎患者分为多沙唑嗪治疗的多沙唑嗪组（n＝31）、高压氧治疗的高压氧组（n＝28）和多沙唑嗪联合高压氧治疗的联合治疗组（n＝35），治疗时间为8周；治疗前、后分别进行前列腺液常规、前列腺液细菌培养、精液精子计数、精子活动度等检查。采用慢性前列腺炎症状指数评分（NIH-CPSI）对症状及疗效进行评测和比较，并记录不良反应。结果3组患者治疗前较治疗后在疼痛或不适症状评分、排尿症状评分、生活质量评分及总分4项均有明显改善；联合治疗组总有效率（82．9％）较多沙唑嗪组（70．0％）、高压氧组（73．7％）显著，差异有统计学意义（ P＜0．05）。3组患者治疗后前列腺液常规均有一定好转，联合治疗组变化最为明显，差异有统计学意义（P＜0．05）。3组患者治疗前精液精子计数、精子活动度较健康人均有一定程度降低，治疗后联合治疗组有明显改善，差异有统计学意义（P＜0．05）。无并发症发生。结论高压氧联合甲磺酸多沙唑嗪治疗高原条件下Ⅲ型前列腺炎安全有效。
목적：탐토고압양연합다사서진치료고원조건하Ⅲ형전렬선염적료효화궤제。방법장94례Ⅲ형전렬선염환자분위다사서진치료적다사서진조（n＝31）、고압양치료적고압양조（n＝28）화다사서진연합고압양치료적연합치료조（n＝35），치료시간위8주；치료전、후분별진행전렬선액상규、전렬선액세균배양、정액정자계수、정자활동도등검사。채용만성전렬선염증상지수평분（NIH-CPSI）대증상급료효진행평측화비교，병기록불량반응。결과3조환자치료전교치료후재동통혹불괄증상평분、배뇨증상평분、생활질량평분급총분4항균유명현개선；연합치료조총유효솔（82．9％）교다사서진조（70．0％）、고압양조（73．7％）현저，차이유통계학의의（ P＜0．05）。3조환자치료후전렬선액상규균유일정호전，연합치료조변화최위명현，차이유통계학의의（P＜0．05）。3조환자치료전정액정자계수、정자활동도교건강인균유일정정도강저，치료후연합치료조유명현개선，차이유통계학의의（P＜0．05）。무병발증발생。결론고압양연합갑광산다사서진치료고원조건하Ⅲ형전렬선염안전유효。
Objective To investigate the effect of treatment and mechanism with hyperbaric oxygenation and doxazosin in pa-tients with Ⅲ type prostatitis in plateau .Methods A total of 94 patients with Ⅲ type prostatitis were divided randomizedly into hyperbaric oxygenation group (n=28) ,doxazosin treated group (n=31) and hyperbaric oxygenation and doxazosin combining trea-ted group (n= 35) .And then they were evaluated in 8 weeks treatment respectvely by the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) and adverse events .Prostate fluid and semen routine were examed .Results All three groups got the improved CPSI after treatment ,oxygenation-doxazosin combining treated group(82 .9% )was better than that of oxy-genation and doxazosin treated group(73 .7% and 70 .0% )(P<0 .05) .Results of prostate fluid and semen routine examination of combining treated group were significantly improved than before (P<0 .05) .No complications occurred .Conclusion Combination of hyperbaric oxygenation and doxazosin is a safe and effective therapy in the treatment of Ⅲ type prostatitis in plateau .