CAJ | 학술논문

目的：探讨手术治疗老年肺鳞状细胞癌患者预后的影响因素。方法收集老年肺鳞状细胞癌患者210例均行手术治疗，结合辅助治疗，术后随访。采用Kaplan-Meier法分析患者预后1、3、5年的生存率，逐步Cox回归分析预后的影响因素。结果术后1、3、5年生存率分别为89．0％、68．6％、56．2％。术前有无吸烟史、纵隔淋巴结异常程度、TNM分期以及清扫淋巴结的组数、纵隔淋巴结清扫组数对肺鳞状细胞癌患者生存率的影响显著，差异有统计学意义（P＜0．05）。术前有无吸烟史（χ2＝16．198，P＝0．000）、术前纵隔淋巴结异常程度（χ2＝8．873，P＝0．003）、TNM分期（χ2＝18．718，P＝0．000）、纵隔淋巴结清扫组数（χ2＝4．897，P＝0．027）是肺鳞状细胞癌患者预后的影响因素。结论术前TNM分期准确与影像检查淋巴结肿大，对手术适应证的把握就更合适，控制吸烟以及纵隔淋巴结清扫的组数越多，越有利于提高患者预后的生存率。
목적：탐토수술치료노년폐린상세포암환자예후적영향인소。방법수집노년폐린상세포암환자210례균행수술치료，결합보조치료，술후수방。채용Kaplan-Meier법분석환자예후1、3、5년적생존솔，축보Cox회귀분석예후적영향인소。결과술후1、3、5년생존솔분별위89．0％、68．6％、56．2％。술전유무흡연사、종격림파결이상정도、TNM분기이급청소림파결적조수、종격림파결청소조수대폐린상세포암환자생존솔적영향현저，차이유통계학의의（P＜0．05）。술전유무흡연사（χ2＝16．198，P＝0．000）、술전종격림파결이상정도（χ2＝8．873，P＝0．003）、TNM분기（χ2＝18．718，P＝0．000）、종격림파결청소조수（χ2＝4．897，P＝0．027）시폐린상세포암환자예후적영향인소。결론술전TNM분기준학여영상검사림파결종대，대수술괄응증적파악취경합괄，공제흡연이급종격림파결청소적조수월다，월유리우제고환자예후적생존솔。
Objective To explore influence factors of gerontal patients with lung squamous carcinoma after surgical therapy . Methods 210 gerontal patients with lung squamous carcinoma were accepted surgical therapy and adjuvant therapy ,and were fol-lowed up .The survival rates of 1 ,3 and 5 years after the surgery were evaluated by Kaplan-Meier ,and influence factors were ana-lyzed by Cox regression .Results The 1 ,3 and 5 years survival rates were 89 .0% ,68 .6% and 56 .2% ,respectively .The survival rates were significantly influenced by the smoking history ,the abnormal degree of mediastinal lymph node ,TNM stage ,the class number of lymph node dissection ,and the class number of mediastinal lymph node dissection(P<0 .05) .The smoking history(χ2 =16 .198 ,P=0 .000) ,the abnormal degree of mediastinal lymph node(χ2 =8 .873 ,P=0 .003) ,TNM stage(χ2 =18 .718 ,P=0 .000) , and the class number of mediastinal lymph node dissection (χ2 =4 .897 ,P=0 .027) were the influence factors of prognostic .Conclu-sion The accurate TNM staging and mediastinal lymph node with image examination could be more appropriate to operative indica-tions ,meanwhile ,if smoking was controlled ,the class number of mediastinal lymph node dissection was more .These could be bene-ficial to the survival .