CAJ | 학술논문

青光眼、视神经炎或眼外伤可累及视神经,导致视力的不可逆性损害甚至失明,视神经的有效再生对于挽救患者的视力、提高患者的生活质量、减轻患者的家庭负担和社会负担无疑具有重要意义.近年来围绕视神经再生的问题,通过调节细胞信号通路和应用神经胶质细胞、神经干细胞、神经营养因子等方法取得了一定的进展,这些进展为视神经损伤性疾病的治疗研究提供了一定的理论基础,眼科医师应积极关注和参与相关研究,共同促进视觉再生医学的进步.基于视神经再生影响因素的探讨,总结视神经再生研究的最新进展,提出研究中尚待解决的和值得进一步研究的问题.
청광안、시신경염혹안외상가루급시신경,도치시력적불가역성손해심지실명,시신경적유효재생대우만구환자적시력、제고환자적생활질량、감경환자적가정부담화사회부담무의구유중요의의.근년래위요시신경재생적문제,통과조절세포신호통로화응용신경효질세포、신경간세포、신경영양인자등방법취득료일정적진전,저사진전위시신경손상성질병적치료연구제공료일정적이론기출,안과의사응적겁관주화삼여상관연구,공동촉진시각재생의학적진보.기우시신경재생영향인소적탐토,총결시신경재생연구적최신진전,제출연구중상대해결적화치득진일보연구적문제.
Glaucoma,optical neuritis and trauma are optic nerve injury-related diseases.These ocular diseases cause irreversible damage of the vision and even blindness.The study on optic nerve regeneration is a powerful approach for rescuing vision and improving the quality of life of patients.Therefore,how to promote optic nerve regeneration is always the focus in ophthalmology.In recent years,great progression has achieved by modulation of cellular signal pathway,usage of glial cells,stem cells and neurotrophic factor,etc,which lays a basis for the treatment of optic nerve injury.Ophthalmologist should trace and participate in these researches to promote the development of regeneration medicine.This review summarizes these new approaches after discussing factors effecting optic nerve regeneration briefly and proposes questions to answer.