CAJ | 학술논문

目的探讨小剂量激素吸入与噻托溴铵联用对支气管哮喘患者血清细胞因子及肺功能的影响及临床疗效.方法选择轻、中度哮喘患者80例,随机分为观察组和对照组各40例,观察组采用小剂量二丙酸倍氯米松吸入与噻托溴铵联合治疗,对照组采用大剂量二丙酸倍氯米松治疗,比较两组患者血清细胞因子、肺功能及哮喘症状评分变化情况.结果治疗后观察组IL-8、IL-10、TNF-α明显低于对照组(P＜0.05),FVC、FEV1、FEV1/FVC明显高于对照组(P＜0.05),哮喘评分明显低于对照组(P＜0.05),不良反应发生率低于对照组(P＜0.05).结论小剂量激素吸入联合噻托溴铵治疗支气管哮喘,临床疗效佳,安全可靠,值得临床推广.
목적 탐토소제량격소흡입여새탁추안련용대지기관효천환자혈청세포인자급폐공능적영향급림상료효.방법 선택경、중도효천환자80례,수궤분위관찰조화대조조각40례,관찰조채용소제량이병산배록미송흡입여새탁추안연합치료,대조조채용대제량이병산배록미송치료,비교량조환자혈청세포인자、폐공능급효천증상평분변화정황.결과 치료후관찰조IL-8、IL-10、TNF-α명현저우대조조(P＜0.05),FVC、FEV1、FEV1/FVC명현고우대조조(P＜0.05),효천평분명현저우대조조(P＜0.05),불량반응발생솔저우대조조(P＜0.05).결론 소제량격소흡입연합새탁추안치료지기관효천,림상료효가,안전가고,치득림상추엄.
Objective To investigate clinical efficacy of low dose of corticosteroid combined with tiotropium bromide on cytokines and pulmonary function of patients with bronchial asthma treated by inhaling.Methods 80 cases of patients with light or moderate asthma were randomly divided into observation group and control group,40 cases for each group.Observation group was treated with inhaling low dose of two beclomethasone dipropionate and tiotropium bromide,control group was treated with high dose of two beclomethasone.The cytokines,pulmonary function and asthma symptom score changes between two groups were compared.Results At post-treatment,the IL-8,IL-10,TNF-α in observation group were significantly lower than those in control group (P ＜ 0.05); the FVC,FEV1,FEV1/FVC (％) in observation group were significantly higher than those in control group (P ＜ 0.05); asthma score was significantly lower than that in control group (P ＜ 0.05); the incidence of adverse reaction was lower than that in control group (P ＜ 0.05).Conclusion Treating bronchial asthma by inhaling low dose of corticosteroid combined with tiotropium bromide has good clinical curative effect,which is safe and reliable,and worthy of clinical application.