航空航天医学杂志
航空航天醫學雜誌
항공항천의학잡지
AEROSPACE MEDICINE
2014年
2期
134-135
,共2页
宫颈癌%宫颈上皮内瘤变%HPV基因%DNA检测%分型
宮頸癌%宮頸上皮內瘤變%HPV基因%DNA檢測%分型
궁경암%궁경상피내류변%HPV기인%DNA검측%분형
cervical cancer%cervical intraepithelial neoplasia%HPV gene%DNA testing%genotyping
目的：分析不同宫颈病变患者中HPV感染的基因分型。方法选择接受宫颈活检的妇女150例为研究对象，进行HPV-DNA检测，分析不同宫颈病变的HPV感染情况及HPV基因型亚型分布情况。结果宫颈鳞状细胞癌患者的HPV感染阳性率94.74％，CINⅢHPV感染阳性率71.43％，均远高于其他宫颈病变类型患者（ P＜0.05）；高危基因型感染率为94.92％，其中前三位为HPV16、HPV51、HPV58，低危基因型包括HPV6、HPV11共3例（5.08％）。结论 HPV感染率随着宫颈病变的严重程度上升而上升，通过对HPV进行亚型检测，有助于早期宫颈癌的预警及治疗，改善患者预后。
目的：分析不同宮頸病變患者中HPV感染的基因分型。方法選擇接受宮頸活檢的婦女150例為研究對象，進行HPV-DNA檢測，分析不同宮頸病變的HPV感染情況及HPV基因型亞型分佈情況。結果宮頸鱗狀細胞癌患者的HPV感染暘性率94.74％，CINⅢHPV感染暘性率71.43％，均遠高于其他宮頸病變類型患者（ P＜0.05）；高危基因型感染率為94.92％，其中前三位為HPV16、HPV51、HPV58，低危基因型包括HPV6、HPV11共3例（5.08％）。結論 HPV感染率隨著宮頸病變的嚴重程度上升而上升，通過對HPV進行亞型檢測，有助于早期宮頸癌的預警及治療，改善患者預後。
목적：분석불동궁경병변환자중HPV감염적기인분형。방법선택접수궁경활검적부녀150례위연구대상，진행HPV-DNA검측，분석불동궁경병변적HPV감염정황급HPV기인형아형분포정황。결과궁경린상세포암환자적HPV감염양성솔94.74％，CINⅢHPV감염양성솔71.43％，균원고우기타궁경병변류형환자（ P＜0.05）；고위기인형감염솔위94.92％，기중전삼위위HPV16、HPV51、HPV58，저위기인형포괄HPV6、HPV11공3례（5.08％）。결론 HPV감염솔수착궁경병변적엄중정도상승이상승，통과대HPV진행아형검측，유조우조기궁경암적예경급치료，개선환자예후。
Objective To analyze the genotyping of HPV infection in the different cervical lesions.Methods 150 patients for cervical biopsy in our hospital were studied by HPV -DNA testing.Different HPV infection in cervical lesions and HPV genotype subtype distribution were analyzed.Results The positive rate of HPV infection for patients with cer-vical squamous cell carcinoma was 94.74%,the positive rate of HPV infection with CIN Ⅲ was 71.43% ,were higher than those patients with other types of cervical lesions ( P <0.05 ).Risk genotype infection rate for patients was 94.92%,of which the first three genotype was HPV16,HPV51,HPV58.There were 3 cases (5.08%) about low -risk genotypes with HPV6, HPV11.Conclusions The infection rate of HPV rise up by the severity of cervical lesions. HPV genotypes testing can contribute to early warning and treatment of cervical cancer ,improve the outcomes of patients.
