中国现代医药杂志
中國現代醫藥雜誌
중국현대의약잡지
MODERN MEDICINE JOURNAL OF CHINA
2014年
4期
40-42
,共3页
髓性%白血病%甲磺酸伊马替尼%疗效
髓性%白血病%甲磺痠伊馬替尼%療效
수성%백혈병%갑광산이마체니%료효
Myeloid Leukemia%Imatinib mesylate%Curtiave effect
目的：观察甲磺酸伊马替尼（IM）治疗慢性粒细胞白血病（CML）慢性期（CP）及进展期的疗效。方法回顾性分析2009年1月~2013年12月我院采用IM治疗的60例CML患者临床资料，其中30例为进展期患者，30例为CP患者。结果进展期患者DA化疗后血液学完全缓解0例，部分缓解6例，未缓解24例，总有效率20%；行IM治疗后完全缓解13例，部分缓解6例，未缓解11例，总有效率63.3%，两者治疗有效率差异有统计学意义（χ2=4.36，P＜0.05）。30例CP患者行IM治疗后完全缓解26例，部分缓解0例，未缓解4例，总有效率86.7%，进展期及CP组IM治疗有效率差异有统计学意义（χ2=11.59，P＜0.05）；进展期患者中McyR 及CmoR 的患者分别为10例（33.3%）和6例（20%）；CP 组分别为26例（86.7%）和24例（80%）；CP患者IM治疗后遗传学疗效较进展期好。结论 IM是各期CML的理想治疗方法，有效率高。血液学毒性是其主要副作用，其余反应较轻，患者耐受良好。
目的：觀察甲磺痠伊馬替尼（IM）治療慢性粒細胞白血病（CML）慢性期（CP）及進展期的療效。方法迴顧性分析2009年1月~2013年12月我院採用IM治療的60例CML患者臨床資料，其中30例為進展期患者，30例為CP患者。結果進展期患者DA化療後血液學完全緩解0例，部分緩解6例，未緩解24例，總有效率20%；行IM治療後完全緩解13例，部分緩解6例，未緩解11例，總有效率63.3%，兩者治療有效率差異有統計學意義（χ2=4.36，P＜0.05）。30例CP患者行IM治療後完全緩解26例，部分緩解0例，未緩解4例，總有效率86.7%，進展期及CP組IM治療有效率差異有統計學意義（χ2=11.59，P＜0.05）；進展期患者中McyR 及CmoR 的患者分彆為10例（33.3%）和6例（20%）；CP 組分彆為26例（86.7%）和24例（80%）；CP患者IM治療後遺傳學療效較進展期好。結論 IM是各期CML的理想治療方法，有效率高。血液學毒性是其主要副作用，其餘反應較輕，患者耐受良好。
목적：관찰갑광산이마체니（IM）치료만성립세포백혈병（CML）만성기（CP）급진전기적료효。방법회고성분석2009년1월~2013년12월아원채용IM치료적60례CML환자림상자료，기중30례위진전기환자，30례위CP환자。결과진전기환자DA화료후혈액학완전완해0례，부분완해6례，미완해24례，총유효솔20%；행IM치료후완전완해13례，부분완해6례，미완해11례，총유효솔63.3%，량자치료유효솔차이유통계학의의（χ2=4.36，P＜0.05）。30례CP환자행IM치료후완전완해26례，부분완해0례，미완해4례，총유효솔86.7%，진전기급CP조IM치료유효솔차이유통계학의의（χ2=11.59，P＜0.05）；진전기환자중McyR 급CmoR 적환자분별위10례（33.3%）화6례（20%）；CP 조분별위26례（86.7%）화24례（80%）；CP환자IM치료후유전학료효교진전기호。결론 IM시각기CML적이상치료방법，유효솔고。혈액학독성시기주요부작용，기여반응교경，환자내수량호。
Objective To investigate the curative effect of the chronic myeloid leukemia (CML) patients treated with i-matinib (IM) mesylate in chronic phase (CP) and advanced phase. Methods The clinical data of 60 cases treated with ima-tinib mesylate in our hospital selected from Jan 2009 to Dec 2013 were analysed retrospectively. Results 0 case had complete response in the 30 advanced phase treated by DA cosmetic treatment, 6 cases had the part response, 24 cases had no response, the efficient rate was 20%. 13 cases had complete significant response in the 30 advanced phase treated by IM , 6 cases had the part response,11 cases had no response, the efficient rate was 63.3%,there were significant differences between the two groups (χ2=4.36,P<0.05). 26 cases had complete response in the CP group treated by IM,4 cases had no response, the efficient rate was 86.7%, there were significant differences between CP and advanced phase treated by IM. The complete cytogenetic re-sponse and complete molecular genetic response was 33.3%,20%in the advanced phase and the CP was 86.7%,80%. CP group treated by IM had better genetics curative effect than advanced phase group. Conclusion IM is a good way to cure CML,it has high efficient. It's side-effect is toxicity blood system,other bad reaction is little, patient tolerance is better.
