CAJ | 학술논문

目的：本文旨在分析生长激素缺乏症患儿应用重组人生长激素治疗后血清胰岛素样生长因子-1（IGF -1）、胰岛素样生长因子结合蛋白3（IGFBP -3）以及两者比值（IGF -1/IGFBP -3）三项指标的变化情况及探讨其在疗效评估中的价值。方法：选择2011年1月至2014年2月在我院确诊生长激素缺乏症（growth hormone deficiency ，GHD）并接受重组人生长激素（recombinant human growth hormone ，rhGH）治疗的矮小患儿44例为研究对象，于治疗前、治疗3个月、治疗6个月分别检测/计算三项指标，分析变化规律，研究其与身高生长速度（growth velocity ，GV）的相关性。结果：1．治疗3个月后IGF -1SDS显著增高，但IGFBP -3SDS、IGF -1/IGFBP -3 SDS无明显变化；2．治疗6个月后的IGF -1SDS、IGF -1/IGFBP -3SDS明显增高，但IGFBP -3SDS无明显改变；3．治疗3个月的GV 与治疗前后的IGF -1、IGFBP -3、IGF -1/IGFBP -3SDS 及这三项指标的变化均无明显相关；治疗后6个月GV 与治疗前IGF -1SDS呈负相关，而与6个月内的IGF-1SDS 变化值呈正相关；GV 与治疗前的 IGFBP -3、IGF -1/IGFBP -3SDS以及两者6月内的变化值均无明显关系，与治疗6个月后的这三项指标亦无显著相关。结论：IGF -1可能有助于 GHD 疗效的判断。
목적：본문지재분석생장격소결핍증환인응용중조인생장격소치료후혈청이도소양생장인자-1（IGF -1）、이도소양생장인자결합단백3（IGFBP -3）이급량자비치（IGF -1/IGFBP -3）삼항지표적변화정황급탐토기재료효평고중적개치。방법：선택2011년1월지2014년2월재아원학진생장격소결핍증（growth hormone deficiency ，GHD）병접수중조인생장격소（recombinant human growth hormone ，rhGH）치료적왜소환인44례위연구대상，우치료전、치료3개월、치료6개월분별검측/계산삼항지표，분석변화규률，연구기여신고생장속도（growth velocity ，GV）적상관성。결과：1．치료3개월후IGF -1SDS현저증고，단IGFBP -3SDS、IGF -1/IGFBP -3 SDS무명현변화；2．치료6개월후적IGF -1SDS、IGF -1/IGFBP -3SDS명현증고，단IGFBP -3SDS무명현개변；3．치료3개월적GV 여치료전후적IGF -1、IGFBP -3、IGF -1/IGFBP -3SDS 급저삼항지표적변화균무명현상관；치료후6개월GV 여치료전IGF -1SDS정부상관，이여6개월내적IGF-1SDS 변화치정정상관；GV 여치료전적 IGFBP -3、IGF -1/IGFBP -3SDS이급량자6월내적변화치균무명현관계，여치료6개월후적저삼항지표역무현저상관。결론：IGF -1가능유조우 GHD 료효적판단。
Objective :To explore the relationship between growth response and the changes in insulin -like growth factor 1 (IGF -1) ,insulin -like growth factor binding protein 3 (IGFBP -3) and the IGF -I/IGFBP -3 molar ratio during recombinant human growth hormone (rhGH) treat-ment in growth hormone deficiency (GHD) children .Methods :The study includes 44 GHD children diagnosed in the first affiliated Hospital of Guangxi Medical University from January 2011 to February 2014 and treated with rhGH .Serum IGF -1 ,IGFBP -3 were measured before treatment and after 3 months ,6 months of treatment respectively .IGF -I ,IGFBP -3 and IGF -I/IGFBP -3 were expressed as SD scores using reference values from the normal population .Analysis the changes of IGF -1SDS ,IGFBP -3SDS ,IGF -1/IGFBP -3SDS after 3 months ,6 months of treatment and their cor-relation with growth velocity .Results:(1) After 3 months ,IGF -1SDS were significantly higher than pretreatment while IGFBP -3SDS ,IGF -1/IG-FBP -3SDS without obvious difference ;(2)Compared to pretreatment ,IGF -1SDS ,IGF -1/IGFBP -3SDS measured after 6 month were significant-ly higher ,while IGFBP -3SDS has no statistical difference ;(3)Baseline IGF -1SDS ,IGFBP -3SDS ,IGF -1/IGFBP -3SDS and GV in the first 3 months had no significantly relation ;the GV in 6 month is negatively correlated with baseline IGF -1SDS and positively correlated with the changing of IGF -1SDS significantly .;After 6 months ,the GV had no relationship with baseline IGFBP -3SDS ,IGF -1/IGFBP -3SDS and IGF -1SDS ,IG-FBP -3SDS ,IGF -1/IGFBP -3SDS measured at 6 month later .Conclusion:IGF -1 may help predict the efficacy of rhGH treatment in GHD chil-dren .