CAJ | 학술논문

目的：比较非小细胞肺癌（NSCLC）调强放射治疗计划中采用6 MV与10 MV-X射线治疗的计量学差异．方法随机选取20例NSCLC患者，分别采用6 MV与10 MV-X射线对每例NSCLC进行IMRT的计划设计，应用ADAC Pinnacle8.0f治疗计划系统提供的卷积/迭代算法，对相同的靶区运用2种能量进行IMRT计划设计，通过比较剂量体积直方图（DVH）、PTV参数（Dmean、Dmin、Dmax）、适形指数（CI）及均匀性指数（HI），分析计量学参数．结果6 MV与10 MV放疗计划的DVH、PTV参数、CI、HI及等剂量线相近，并无明显统计学差异（＞0.05），6 MV计划的靶区剂量均匀性及高剂量覆盖靶区程度略优于10 MV计划，正常肺组织、食管、心脏、脊髓等危及器官（OAR）的受量基本相同．结论对于NSCLC的放射治疗建议优先6MV-X线．
목적：비교비소세포폐암（NSCLC）조강방사치료계화중채용6 MV여10 MV-X사선치료적계량학차이．방법수궤선취20례NSCLC환자，분별채용6 MV여10 MV-X사선대매례NSCLC진행IMRT적계화설계，응용ADAC Pinnacle8.0f치료계화계통제공적권적/질대산법，대상동적파구운용2충능량진행IMRT계화설계，통과비교제량체적직방도（DVH）、PTV삼수（Dmean、Dmin、Dmax）、괄형지수（CI）급균균성지수（HI），분석계량학삼수．결과6 MV여10 MV방료계화적DVH、PTV삼수、CI、HI급등제량선상근，병무명현통계학차이（＞0.05），6 MV계화적파구제량균균성급고제량복개파구정도략우우10 MV계화，정상폐조직、식관、심장、척수등위급기관（OAR）적수량기본상동．결론대우NSCLC적방사치료건의우선6MV-X선．
Objective To compare the effects of 6MV and 10MV-X-ray intensity modulated radiotherapy (IMRT) on non-small-cell lung cancer (NSCLC) . Methods We randomly selected 20 patients with NSCLC, 6MV and 10MV X-ray were used respectively for each NSCLC patient with IMRT plan design, the ADAC Pinnacle 8.0f treatment planning system was applied to provide the convolution/iteration algorithm, for the same target IMRT plan design with two kinds of energy. By comparing the dose volume histogram (DVH),PTV parameter (Dmean, Dmin and Dmax), conformal index (CI) and homogeneity index (HI),we analyzed the metrology parameters . Results 6MV and 10MV radiation therapy plan DVH, PTV parameters,CI,HI and isodose line was similar,no statistically significant differences. But target dose homogeneity and the degree of target coverage in high dose of 6MV plan was better than that in 10MV plan. Endanger organs (OAR) such as normal lung tissue, heart, esophagus and spinal cord had basically same dose amount. Conclusion 6MV X-ray plan may be the better choice of radiotherapy on NSCLC.