CAJ | 학술논문

目的：探讨慢性乙型肝炎患者血浆脂氧素A4水平与疾病临床分度的关系．方法选取病毒性肝炎乙型慢性轻度患者34例、慢性中度患者30例，慢性重度患者30例，采集患者外周静脉血分离血浆，应用酶联免疫方法测定血浆脂氧素A4的含量，分析脂氧素A4与慢性乙型肝炎临床分度的关系．结果慢性重度肝炎患者外周血脂氧素A4水平显著低于慢性轻度患者和慢性中度患者（＜0.05），和疾病临床分度显著相关．外周血血浆脂氧素A4的含量与ALT和AST的水平均成负相关，相关系数为分别为＝-0.41，＝0.019和＝-0.37，＝0.034．结论外周血血浆脂氧素A4的含量与慢性乙型肝炎临床分度相关．
목적：탐토만성을형간염환자혈장지양소A4수평여질병림상분도적관계．방법선취병독성간염을형만성경도환자34례、만성중도환자30례，만성중도환자30례，채집환자외주정맥혈분리혈장，응용매련면역방법측정혈장지양소A4적함량，분석지양소A4여만성을형간염림상분도적관계．결과만성중도간염환자외주혈지양소A4수평현저저우만성경도환자화만성중도환자（＜0.05），화질병림상분도현저상관．외주혈혈장지양소A4적함량여ALT화AST적수평균성부상관，상관계수위분별위＝-0.41，＝0.019화＝-0.37，＝0.034．결론외주혈혈장지양소A4적함량여만성을형간염림상분도상관．
Objective To explore the correlation between serum Lipoxin A4 and clinical grading of chronic hepatitis B patients. Method The serum Lipoxin A4 was detected by Enzyme-Linked Immunosorbent Assay in 94 chronic hepatitis B patients. Results It was found that the level of serum Lipoxin A4 of severe hepatitis patients were significantly lower than mild hepatitis patients and moderate hepatitis patients ( =0.04 and =0.03) . The serum Lipoxin A4 levels were correlated negatively with the ALT and AST levels,respectively =-0.41, =0.019 and R=-0.37,P=0.034. Conclusion These findings support the fact that the serum Lipoxin A4 may contribute to clinical grading of chronic hepatitis B patients.