CAJ | 학술논문

目的：探讨长方案中长效与短效达菲林的垂体降调节效果及体外受精-胚胎移植的妊娠结局．方法行体外受精助孕的患者317例，均于前1月经周期黄体中期开始注射达菲林．随机分为2组，A组（145例）皮下注射长效达菲林1.25 mg，单次给药；B组（172例）每天皮下注射短效达菲林0.1 mg，14～18 d降调节后减量至每天注射0.05 mg，直到HCG注射日．结果（1）促性腺激素使用天数及用量：A组[（11.8±2.1） d，（31.2±9.5）支]显著多于B组[（10.1±1.3） d，（25.4±9.3）支]，＜0.05；（2）2组患者的获卵数、受精率、优质胚胎数、着床率比较差异无统计学意义（＞0.05）；（3）临床妊娠率：2组比较差异无统计学意义（＞0.05），但B组有增高趋势．结论长方案中短效达菲林的垂体降调节效果与长效达菲林相似，而促性腺激素用量更少，使用更灵活，值得推荐．
목적：탐토장방안중장효여단효체비림적수체강조절효과급체외수정-배태이식적임신결국．방법행체외수정조잉적환자317례，균우전1월경주기황체중기개시주사체비림．수궤분위2조，A조（145례）피하주사장효체비림1.25 mg，단차급약；B조（172례）매천피하주사단효체비림0.1 mg，14～18 d강조절후감량지매천주사0.05 mg，직도HCG주사일．결과（1）촉성선격소사용천수급용량：A조[（11.8±2.1） d，（31.2±9.5）지]현저다우B조[（10.1±1.3） d，（25.4±9.3）지]，＜0.05；（2）2조환자적획란수、수정솔、우질배태수、착상솔비교차이무통계학의의（＞0.05）；（3）림상임신솔：2조비교차이무통계학의의（＞0.05），단B조유증고추세．결론장방안중단효체비림적수체강조절효과여장효체비림상사，이촉성선격소용량경소，사용경령활，치득추천．
Objective To explore the efficacy of long- and short-acting triptorelin on pituitary down-regulation in long protocol and the pregnancy outcome in vitro fertilization and embryo transfer (IVF-ET) . Methods Three hundred and seventeen patients for IVF-ET were enrolled as study and randomized them into two groups. In group A (n=145), patients received single dose subcutaneous injection of 1.25 mg long-acting diphereline in mid-luteal phase. In group B (n=172), patients received 0.1 mg/d subcutaneous injection of short-acting diphereline in mid-luteal phase for 14-18 days until pituitary suppression were got,and then reduced to 0.05 mg/d until the injection of HCG. Results The dose and the days of gonadotropin administration in group A were bigger and longer than those in group B ( <0.05) . There were no significant differences in the number of retrieved oocytes, fertilization rate,high quality embryos,implantation rate and clinical pregnancy rate between the two groups (all > 0.05) . But clinical pregnancy rate of group B had increasing trend. Conclusion Administration of short-acting diphereline has the similar effect with that of long-acting diphereline on pituitary down-regulation in long protocol. Short-acting diphereline requires lower amount of gonadotropin and is more flexible,so it should be recommended.