CAJ | 학술논문

目的：探讨血管紧张素原AGTM235T基因多态性分布情况，比较频数分布在中老年高血压及中老年高血压并抑郁症患者中是否存在差异，研究与中老年高血压及中老年高血压并抑郁症易感性的相关性．方法运用引物序列特异性聚合酶链反应（PCR）及基因测序的方法检测117例高血压患者组及91例高血压并抑郁症患者组、101例健康对照组AGT M235T基因多态性．结果中老年高血压患者组及中老年高血压并抑郁症患者组AGT M235T基因型TT与T等位基因频率与健康对照组AGT M235T TT基因型分布频率具有统计学差异（＜0.05）．结论 AGT基因M235T多态性与中老年高血压及中老年高血压并抑郁症的发病风险具有明显相关性．
목적：탐토혈관긴장소원AGTM235T기인다태성분포정황，비교빈수분포재중노년고혈압급중노년고혈압병억욱증환자중시부존재차이，연구여중노년고혈압급중노년고혈압병억욱증역감성적상관성．방법운용인물서렬특이성취합매련반응（PCR）급기인측서적방법검측117례고혈압환자조급91례고혈압병억욱증환자조、101례건강대조조AGT M235T기인다태성．결과중노년고혈압환자조급중노년고혈압병억욱증환자조AGT M235T기인형TT여T등위기인빈솔여건강대조조AGT M235T TT기인형분포빈솔구유통계학차이（＜0.05）．결론 AGT기인M235T다태성여중노년고혈압급중노년고혈압병억욱증적발병풍험구유명현상관성．
Objective To investigate the correlation between angiotensinogen gene M235T polymorphism and gerontism hypertension combined with depression. Methods The polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) technique were used to detect the M235T genetic polymorphism in 117 patients with hypertension and 91 patients with hypertension and depression, and 101 healthy subjects without clinical evidence of hypertension and depression.Result The frequency of TT genetype and T allele was higher in group with hypertension and the group with hypertension and depression than that in the control group ( <0.05) . Conclusion Angiotensinogen gene M235T polymorphism is significantly correlated with the gerontism hypertension combined with depression.