CAJ | 학술논문

目的：探讨中药复方ZDS对烧伤后消化道氧自由基损害的保护作用．方法20只SD大鼠随机分为中药复方ZDS组（ZDS，n＝10）和单纯烫伤组（Con，n＝10），复制30%TBSA III度烫伤模型后分别于伤后2 h开始给予ZDS或温水灌喂，2 mL/次，2次/d．并于伤后第3、9天观察门静脉血清超氧化物歧化酶（SOD）活力、丙二醛（MDA）水平、肠外组织器官细菌移位率（BT）及肠粘膜病理学改变．结果 ZDS组伤后第9天门静脉血清SOD活力显著高于Con组（＜0.05），而MDA水平则低于Con组（＜0.05）．结论中药复方ZDS可在一定程度上降低烧伤后消化道氧自由基损害．
목적：탐토중약복방ZDS대소상후소화도양자유기손해적보호작용．방법20지SD대서수궤분위중약복방ZDS조（ZDS，n＝10）화단순탕상조（Con，n＝10），복제30%TBSA III도탕상모형후분별우상후2 h개시급여ZDS혹온수관위，2 mL/차，2차/d．병우상후제3、9천관찰문정맥혈청초양화물기화매（SOD）활력、병이철（MDA）수평、장외조직기관세균이위솔（BT）급장점막병이학개변．결과 ZDS조상후제9천문정맥혈청SOD활력현저고우Con조（＜0.05），이MDA수평칙저우Con조（＜0.05）．결론중약복방ZDS가재일정정도상강저소상후소화도양자유기손해．
Objective To investigate the protective effects of Chinese medicine compound ZDS against digestive tact damage caused by oxygen free radical after the burns. Methods 20 SD rats were randomly divided into ZDS (with ZDS treatment,n=10) and Con (control,n=10) groups. The rats were inflicted with 30%TBSA full thickness burn on the back and fed with Chinese medicine compound ZDS or warm water (2 mL/time,2 times a day) . On the 3rd and 9th postburn day, the serum samples were harvested from portal vein and the serum superoxide dismutase (SOD) activity,the levels of malondiadehycle (MDA) were detected. Meanwhile, the bacteria translocation of parenteral organs and the histology of intestine were also observed. Results The SOD activity in ZDS group on day 9 post burn increased significantly than that in Con group( <0.05);but at the same timepoint, compared with Con group, the MDA level in ZDS group was decreased obviously ( <0.05) . Conclusion Chinese medicine compound ZDS can partly protect the digestive tact against damage caused by oxygen free radical after the burns.