河北中医
河北中醫
하북중의
HEBEI JORNAL OF TRADITIONAL CHINESE MEDICINE
2014年
2期
171-174
,共4页
埋线%多囊卵巢综合征%胰岛素
埋線%多囊卵巢綜閤徵%胰島素
매선%다낭란소종합정%이도소
Polycystic ovarian syndrome%Insulin%Catgut embedding
目的：观察穴位埋线联合二甲双胍治疗肾虚痰湿型多囊卵巢综合征（ PCOS）胰岛素抵抗的临床疗效。方法将100例PCOS患者随机分为治疗组和对照组，各50例。对照组予盐酸二甲双胍片治疗，治疗组在对照组基础上在非月经期加用穴位埋线治疗。观察比较2组治疗前后体质量指数（ BMI）、血糖和胰岛素相关指标[空腹血糖（ FPG）、餐后2 h血糖（2 hPG）、空腹胰岛素、餐后2 h胰岛素、稳态模型的胰岛素抵抗指数（HOMA-IR）、稳态模型的胰岛素β细胞分泌指数（HOMA-β）]、血脂相关指标[总胆固醇（TC）、甘油三酯（ TG）、高密度脂蛋白胆固醇（ HDL-C）、低密度脂蛋白胆固醇（ LDL-C）、载脂蛋白A（ Apo-A）及载脂蛋白B（Apo-B）]及性激素相关指标[促黄体生成激素（LH）、卵泡刺激素（FSH）、雌二醇（E2）、睾酮（T）、LH/FSH比值]的水平变化。结果2组治疗后BMI 均明显下降（P＜0．05），且组间比较差异有统计学意义（P＜0．05）；治疗组治疗后FPG、空腹胰岛素、2 hPG、餐后2 h胰岛素、HOMA-IR指数及HOMA-β指数均明显降低（P＜0．05），对照组治疗后仅FPG、空腹胰岛素、HOMA-IR指数及HOMA-β指数明显降低（P＜0．05），且治疗组治疗后空腹胰岛素、餐后2 h胰岛素及HOMA-IR指数水平变化与对照组治疗后比较差异有统计学意义（P＜0．05）；治疗组治疗后TG、LDL-C及Apo-A均降低、HDL-C升高（P＜0．05），对照组治疗后仅TG及LDL-C降低、HDL-C升高（ P＜0．05），且治疗组治疗后TG、HDL-C、LDL-C及Apo-A水平变化与对照组治疗后比较差异有统计学意义（P＜0．05）；治疗组治疗后LH、LH/FSH及T水平均明显降低（P＜0．05），对照组治疗后仅LH及T水平明显降低（P＜0．05），且治疗组治疗后LH及LH/FSH水平变化与对照组治疗后比较差异有统计学意义（P＜0．05）。结论穴位埋线联合二甲双胍片治疗肾虚痰湿型PCOS胰岛素抵抗可以明显改善患者临床症状，降低患者BMI，纠正患者血糖、血脂代谢异常，改善患者胰岛素抵抗，调整性激素水平，可有效治疗PCOS。
目的：觀察穴位埋線聯閤二甲雙胍治療腎虛痰濕型多囊卵巢綜閤徵（ PCOS）胰島素牴抗的臨床療效。方法將100例PCOS患者隨機分為治療組和對照組，各50例。對照組予鹽痠二甲雙胍片治療，治療組在對照組基礎上在非月經期加用穴位埋線治療。觀察比較2組治療前後體質量指數（ BMI）、血糖和胰島素相關指標[空腹血糖（ FPG）、餐後2 h血糖（2 hPG）、空腹胰島素、餐後2 h胰島素、穩態模型的胰島素牴抗指數（HOMA-IR）、穩態模型的胰島素β細胞分泌指數（HOMA-β）]、血脂相關指標[總膽固醇（TC）、甘油三酯（ TG）、高密度脂蛋白膽固醇（ HDL-C）、低密度脂蛋白膽固醇（ LDL-C）、載脂蛋白A（ Apo-A）及載脂蛋白B（Apo-B）]及性激素相關指標[促黃體生成激素（LH）、卵泡刺激素（FSH）、雌二醇（E2）、睪酮（T）、LH/FSH比值]的水平變化。結果2組治療後BMI 均明顯下降（P＜0．05），且組間比較差異有統計學意義（P＜0．05）；治療組治療後FPG、空腹胰島素、2 hPG、餐後2 h胰島素、HOMA-IR指數及HOMA-β指數均明顯降低（P＜0．05），對照組治療後僅FPG、空腹胰島素、HOMA-IR指數及HOMA-β指數明顯降低（P＜0．05），且治療組治療後空腹胰島素、餐後2 h胰島素及HOMA-IR指數水平變化與對照組治療後比較差異有統計學意義（P＜0．05）；治療組治療後TG、LDL-C及Apo-A均降低、HDL-C升高（P＜0．05），對照組治療後僅TG及LDL-C降低、HDL-C升高（ P＜0．05），且治療組治療後TG、HDL-C、LDL-C及Apo-A水平變化與對照組治療後比較差異有統計學意義（P＜0．05）；治療組治療後LH、LH/FSH及T水平均明顯降低（P＜0．05），對照組治療後僅LH及T水平明顯降低（P＜0．05），且治療組治療後LH及LH/FSH水平變化與對照組治療後比較差異有統計學意義（P＜0．05）。結論穴位埋線聯閤二甲雙胍片治療腎虛痰濕型PCOS胰島素牴抗可以明顯改善患者臨床癥狀，降低患者BMI，糾正患者血糖、血脂代謝異常，改善患者胰島素牴抗，調整性激素水平，可有效治療PCOS。
목적：관찰혈위매선연합이갑쌍고치료신허담습형다낭란소종합정（ PCOS）이도소저항적림상료효。방법장100례PCOS환자수궤분위치료조화대조조，각50례。대조조여염산이갑쌍고편치료，치료조재대조조기출상재비월경기가용혈위매선치료。관찰비교2조치료전후체질량지수（ BMI）、혈당화이도소상관지표[공복혈당（ FPG）、찬후2 h혈당（2 hPG）、공복이도소、찬후2 h이도소、은태모형적이도소저항지수（HOMA-IR）、은태모형적이도소β세포분비지수（HOMA-β）]、혈지상관지표[총담고순（TC）、감유삼지（ TG）、고밀도지단백담고순（ HDL-C）、저밀도지단백담고순（ LDL-C）、재지단백A（ Apo-A）급재지단백B（Apo-B）]급성격소상관지표[촉황체생성격소（LH）、란포자격소（FSH）、자이순（E2）、고동（T）、LH/FSH비치]적수평변화。결과2조치료후BMI 균명현하강（P＜0．05），차조간비교차이유통계학의의（P＜0．05）；치료조치료후FPG、공복이도소、2 hPG、찬후2 h이도소、HOMA-IR지수급HOMA-β지수균명현강저（P＜0．05），대조조치료후부FPG、공복이도소、HOMA-IR지수급HOMA-β지수명현강저（P＜0．05），차치료조치료후공복이도소、찬후2 h이도소급HOMA-IR지수수평변화여대조조치료후비교차이유통계학의의（P＜0．05）；치료조치료후TG、LDL-C급Apo-A균강저、HDL-C승고（P＜0．05），대조조치료후부TG급LDL-C강저、HDL-C승고（ P＜0．05），차치료조치료후TG、HDL-C、LDL-C급Apo-A수평변화여대조조치료후비교차이유통계학의의（P＜0．05）；치료조치료후LH、LH/FSH급T수평균명현강저（P＜0．05），대조조치료후부LH급T수평명현강저（P＜0．05），차치료조치료후LH급LH/FSH수평변화여대조조치료후비교차이유통계학의의（P＜0．05）。결론혈위매선연합이갑쌍고편치료신허담습형PCOS이도소저항가이명현개선환자림상증상，강저환자BMI，규정환자혈당、혈지대사이상，개선환자이도소저항，조정성격소수평，가유효치료PCOS。
Objective To observe the effect of acupoint catgut implantation combined with metformin hydro -chloride tablets on renal deficiency and phlegm -damp type polycystic ovarian syndrome ( PCOS) with insulin resist-ance ( IR) .Methods 100 PCOS patients were randomly divided into two groups .50 patients in control group were treated by metformin hydrochloride tablets .50 cases in treatment group were treated by acupoint catgut implantation in the non-menstrual period on the basis of control group treatment .The changes of BMI, FPG, 2 hPG, fasting insulin, postprandial 2h insulin, Homeostasis model of insulin resistance index (HOMA-IR), HOMA-β, T, TG, HDLC, LDL-C, ApoA, APOB,LH, FSH, E2 , T and LH/FSH levels were observed and compared in two groups .Results The levels of BMI after treatment were decreased signif-icantly in two groups (P <0.05), there was difference between groups (P<0.05).The levels of FPG, fasting insulin, 2 hPG, postprandial 2 h insulin, HOMA-IR and HOMA-βafter treatment were obviously decreased in treatment group (P<0.05), but the levels of FPG, fasting insulin, HOMA-IR and HOMA-βafter treatment were decreased in control group (P<0.05).And there were significant differences between two groups on the levels of FPG, fasting insulin and HOMA-IR after treatment (P<0.05).The levels of TG, LDL-C and Apo-A after treat-ment were decreased and the level of HDL -C was increased in treatment group (P<0.05).But in control group the levels of TG and LDL -C were reduced and the level of HDL -C was increased after treatment ( P<0.05 ) .And there were significant differences between two groups on the changes of levels of TG , LDL-C, HDL-C and Apo-A after treatment (P<0.05).The levels of LH, LH/FSH and T after treatment were significantly decreased in treat-ment group (P<0.05).But in control group the levels of LH and T were significantly reduced after treatment (P<0.05).And there was significant difference between two groups on the levels of LH and LH /FSH after treatment (P<0.05).Conclusion Acupoint catgut implantation combined with metformin hydrochloride tablets on renal defi -ciency and phlegm -damp type PCOS with IR can obviously improve clinical symptoms of patients , reduce BMI , cor-rect blood sugar and blood lipid metabolic disturbance , improve IR, regulate levels of hormone and effectively treat P-COS.
