CAJ | 학술논문

目的：观察支气管肺炎患儿T淋巴细胞亚群、免疫球蛋白及补体C3、C4的水平，探讨患儿发生支气管肺炎时免疫功能的变化。方法支气管肺炎患儿58例为观察组，同期儿保门诊经体检为健康正常的小儿共30例为对照组，分别采用流式细胞仪及免疫速率散射比浊法测定两组小儿T淋巴细胞亚群、免疫球蛋白及补体C3、C4的水平，并进行比较分析。结果观察组患儿CD3＋、CD4＋T淋巴细胞及CD4＋/CD8＋比值均明显低于对照组（P＜0．05），而CD8＋T淋巴细胞水平则明显高于对照组（P＜0．05）；观察组IgA、IgM、IgG及补体C3水平均明显低于对照组（P＜0．05），而两组补体C4水平比较，差异无统计学意义（P＞0．05）。结论支气管肺炎患儿机体存在明显的免疫功能紊乱，检测免疫功能对诊断及指导治疗小儿支气管肺炎具有重要临床意义。
목적：관찰지기관폐염환인T림파세포아군、면역구단백급보체C3、C4적수평，탐토환인발생지기관폐염시면역공능적변화。방법지기관폐염환인58례위관찰조，동기인보문진경체검위건강정상적소인공30례위대조조，분별채용류식세포의급면역속솔산사비탁법측정량조소인T림파세포아군、면역구단백급보체C3、C4적수평，병진행비교분석。결과관찰조환인CD3＋、CD4＋T림파세포급CD4＋/CD8＋비치균명현저우대조조（P＜0．05），이CD8＋T림파세포수평칙명현고우대조조（P＜0．05）；관찰조IgA、IgM、IgG급보체C3수평균명현저우대조조（P＜0．05），이량조보체C4수평비교，차이무통계학의의（P＞0．05）。결론지기관폐염환인궤체존재명현적면역공능문란，검측면역공능대진단급지도치료소인지기관폐염구유중요림상의의。
Objective To observe the levels of T lymphocyte subsets ,immunoglobulins and complement C 3,C4 in children with bronchial pneumonia ,and to investigate the changes of immune function in children with bronchial pneumonia . Methods Fifty-eight children with bronchial pneumonia were chosen as observation group ,30 health children who underwent routine health examination in the same period were chosen as control group .The polychromatic flow cytometry and immunoturbidimetry were use to detect the levels of T lymphocyte subsets ,immunoglobulins and complement C3,C4.Results The levels of CD3+,CD4+,and CD4+/CD8+in the observation group were significantly lower than those in the control group (P<0.05),and the level of CD8+in the observation group was significantly higher than that in the control group(P<0.05). The levels of IgA,IgM,IgG and complement C 3 in the observation group were significantly lower than those in the control group(P<0.05).There was no significant difference in the level of complement C 4 between two group(P>0.05). Conclusion Immune dysfunction exists in children with bronchial pneumonia .Immune function test has important clinical significance for the diagnosis and guidance of treating bronchial pneumonia children .