CAJ | 학술논문

目的：探讨亚低温技术对心肺复苏过程中对脑损伤的保护作用。方法将心脏停搏患者48例随机分为亚低温组和常温组，常温组给予常规心脏停搏急救处理。亚低温组在常规处理的基础上给予4℃林格氏液诱导降温联合头颈部体表物理降温，控制肛温在33℃～35℃。对比两组患者复苏成功后24 h、48 h、72 h动脉血乳酸水平、格拉斯哥（ GCS）评分，随访3～6个月，观察脑功能恢复情况。结果亚低温组复苏成功后24 h、48 h、72 h动脉血乳酸浓度显著低于常温组（P＜0．05），GCS评分显著高于常温组（P＜0．05）。随访期间，亚低温组患者疗效显著优于常温组（P＜0．05）。结论心肺复苏早期使用亚低温处理，可以有效减轻缺血缺氧对脑组织的损害，改善神经功能预后。
목적：탐토아저온기술대심폐복소과정중대뇌손상적보호작용。방법장심장정박환자48례수궤분위아저온조화상온조，상온조급여상규심장정박급구처리。아저온조재상규처리적기출상급여4℃림격씨액유도강온연합두경부체표물리강온，공제항온재33℃～35℃。대비량조환자복소성공후24 h、48 h、72 h동맥혈유산수평、격랍사가（ GCS）평분，수방3～6개월，관찰뇌공능회복정황。결과아저온조복소성공후24 h、48 h、72 h동맥혈유산농도현저저우상온조（P＜0．05），GCS평분현저고우상온조（P＜0．05）。수방기간，아저온조환자료효현저우우상온조（P＜0．05）。결론심폐복소조기사용아저온처리，가이유효감경결혈결양대뇌조직적손해，개선신경공능예후。
Objective To explore the protective effect of hypothermia on the brain function after cardiopulmonary resuscitation.Methods Forty-eight patients with cardiac arrest were divided into hypothermia group and normothermia group randomly.The patients in normothermia group were given conventional emergence treatment for cardiac arrest .The patients in hypothermia group were given 4℃Riger′s solution together with physical cooling on the head and neck on the basis of conventional treatment ,and the temperature of anus ranged between 33℃and 35℃.The serum levels of lactic acid in artery,Glasgow coma scale(GCS) scores were measured 24,48,72 hours after cardiopulmonary resusci-tation in both groups.The follow-up lasted for 3 to 6 months,the recovery of patients′brain function was observed.Results The serum levels of lactic acid were significantly lower , and the GCS scores were significantly higher in hypothermia group in contrast with those in normothermia group 24,48,72 hours after cardiopulmonary resuscitation , respectively (P<0.05).During the follow-up,the efficacy of patients in hypothermia group was better than that in normothermia group (P<0.05).Conclusion The early application of hypothermia in cardiopulmonary resuscitation is able to alleviate the damage to brain tissue induced by hypoxia-ischemia and improve the prognosis of nerve function .