CAJ | 학술논문

目的：评估吉西他滨（ GEM）为主的化疗方案治疗晚期原发性肝细胞癌的疗效和安全性。方法晚期原发性肝细胞癌患者89例用GEM为主方案进行化疗，其中GEM＋优氟泰（ UFT ）41例， GEM＋奥沙利铂（L-OHP）48例。按照RECIST 1．1版标准评估疗效，按照CTCAE3．0的毒性标准评估化疗不良反应。结果86例可评价疗效，客观有效率（ORR）及疾病控制率（DCR）分别为19．8％和50．0％；中位生存期为6．2个月，累积半年生存率为53．5％，1年生存率为23．3％，2年生存率为3．5％。 GEM＋UFT方案与GEM＋L-OHP方案的ORR、DCR及中位生存期分别为20．0％、19．6％；47．5％、52．2％；6．0个月、6．3个月，差异无统计学意义（P均＞0．05）。两组不良反应发生率比较，差异无统计学意义（ P均＞0．05）。结论 GEM为主的联合方案治疗晚期肝癌有较好的临床疗效，不良反应可耐受；GEM联合优氟泰方案与GEM联合奥沙利铂方案疗效相似，但前者使用较方便。
목적：평고길서타빈（ GEM）위주적화료방안치료만기원발성간세포암적료효화안전성。방법만기원발성간세포암환자89례용GEM위주방안진행화료，기중GEM＋우불태（ UFT ）41례， GEM＋오사리박（L-OHP）48례。안조RECIST 1．1판표준평고료효，안조CTCAE3．0적독성표준평고화료불량반응。결과86례가평개료효，객관유효솔（ORR）급질병공제솔（DCR）분별위19．8％화50．0％；중위생존기위6．2개월，루적반년생존솔위53．5％，1년생존솔위23．3％，2년생존솔위3．5％。 GEM＋UFT방안여GEM＋L-OHP방안적ORR、DCR급중위생존기분별위20．0％、19．6％；47．5％、52．2％；6．0개월、6．3개월，차이무통계학의의（P균＞0．05）。량조불량반응발생솔비교，차이무통계학의의（ P균＞0．05）。결론 GEM위주적연합방안치료만기간암유교호적림상료효，불량반응가내수；GEM연합우불태방안여GEM연합오사리박방안료효상사，단전자사용교방편。
Objective To evaluate the efficacy and safety of chemotherapy based on gemcitabine ( GEM) for the treatment of advanced primary hepatocellular carcinoma .Methods Eight-nine patients with advanced primary hepatocellular carcinoma recieved chemotherapy based on GEM ,including 41 cases treated with GEM plus UFT and 48 cases treated with GEM plus L-OHP.The efficacy was assessed based on RECIST 1.1,and the adverse events were evaluated according to CTCAE 3.0.Results Eight-six patients were assessable for efficacy .The objective response rate(ORR),disease control rate(DCR) were 19.8%and 50.0%,respectively;The median survival was 6.2 months;The cumulative half-a-year,1-year,2-year survival rates were 53.5%,23.3%and 3.5%,respectively.The ORR,DCR and median survival showed no significant difference between GEM +UFT group and GEM+L-OHP group(20.0%vs. 19.6%,47.5% vs.52.2%,6.0 months vs.6.3 months,all P>0.05).The adverse reactions showed no significant difference between two groups (all P>0.05).Conclusion The combination chemotherapy based on GEM is of good clinical efficacy for the treatment of advanced primary hepatocellular carcinoma ,and the adverse reactions could be tolerated . The efficiency of GEM+UFT regimen is similar to that of GEM +L-OHP regimen ,but the former regimen is of simpler operation.