化工技术与开发
化工技術與開髮
화공기술여개발
TECHNOLOGY & DVELOPMENT OF CHEMICAL INDUSTRY
2014年
2期
16-17
,共2页
霍婷%马洁珺%沈宁%贾庆仪%刘骞峰
霍婷%馬潔珺%瀋寧%賈慶儀%劉鶱峰
곽정%마길군%침저%가경의%류건봉
L-酪氨酸%L-丙氨酸%二肽合成
L-酪氨痠%L-丙氨痠%二肽閤成
L-락안산%L-병안산%이태합성
L-alanyl%L-tyrosine%dipeptide synthesis
以L-酪氨酸和L-丙氨酸为原料，苄氧羰基保护丙氨酸，甲酯保护酪氨酸，EDCI-HOBt法合成丙酪二肽，总摩尔收率(以酪氨酸计)为42%，结构经IR、APCI-MS、NMR表征。
以L-酪氨痠和L-丙氨痠為原料，芐氧羰基保護丙氨痠，甲酯保護酪氨痠，EDCI-HOBt法閤成丙酪二肽，總摩爾收率(以酪氨痠計)為42%，結構經IR、APCI-MS、NMR錶徵。
이L-락안산화L-병안산위원료，변양탄기보호병안산，갑지보호락안산，EDCI-HOBt법합성병락이태，총마이수솔(이락안산계)위42%，결구경IR、APCI-MS、NMR표정。
Methanol was used to protect the carboxyl group of L-tyrosine, carbobenzoxy(Cbz)was selected as the amino protection group of L-alanine, and L-alanyl-L-tyrosine was obtained through the EDCI-HOBt dipeptidesynthesis. The total yield was 42%, the structure was characterized by IR, APCI-MS and NMR.
