化工技术与开发
化工技術與開髮
화공기술여개발
TECHNOLOGY & DVELOPMENT OF CHEMICAL INDUSTRY
2014年
2期
1-3
,共3页
杨建香%邱声祥%佘志刚%林永成
楊建香%邱聲祥%佘誌剛%林永成
양건향%구성상%사지강%림영성
红树林%内生真菌%代谢产物
紅樹林%內生真菌%代謝產物
홍수림%내생진균%대사산물
mangrove%endophytic fungus%metabolites
研究南海红树林内生真菌ZH-3的代谢产物。采用反复硅胶柱色谱法、Sephadex LH-20凝胶色谱法等进行分离纯化,并通过理化常数测定和光谱分析鉴定其化学结构。从南海红树林内生真菌ZH-3的菌体中分离得到4个代谢产物,经波谱解析,分别为2-(3-chloro-2,6-dihydroxy-4-methylbenzoyl)-5-hydroxy-3-methoxybenzoate.(1),3'-dihydroxy-5,5'-dimethyldiphenyl ether(2),7,8-二甲基苯并[g]蝶啶-2,4(1H,3H)-二酮(3),5-o-methylbostrycoidin (4)。初步药理活性显示化合物1对人体肝癌细胞hepG2抑制的IC50值为25μg·mL-1。所有化合物均首次从南海红树林内生真菌ZH-3中分离得到。
研究南海紅樹林內生真菌ZH-3的代謝產物。採用反複硅膠柱色譜法、Sephadex LH-20凝膠色譜法等進行分離純化,併通過理化常數測定和光譜分析鑒定其化學結構。從南海紅樹林內生真菌ZH-3的菌體中分離得到4箇代謝產物,經波譜解析,分彆為2-(3-chloro-2,6-dihydroxy-4-methylbenzoyl)-5-hydroxy-3-methoxybenzoate.(1),3'-dihydroxy-5,5'-dimethyldiphenyl ether(2),7,8-二甲基苯併[g]蝶啶-2,4(1H,3H)-二酮(3),5-o-methylbostrycoidin (4)。初步藥理活性顯示化閤物1對人體肝癌細胞hepG2抑製的IC50值為25μg·mL-1。所有化閤物均首次從南海紅樹林內生真菌ZH-3中分離得到。
연구남해홍수림내생진균ZH-3적대사산물。채용반복규효주색보법、Sephadex LH-20응효색보법등진행분리순화,병통과이화상수측정화광보분석감정기화학결구。종남해홍수림내생진균ZH-3적균체중분리득도4개대사산물,경파보해석,분별위2-(3-chloro-2,6-dihydroxy-4-methylbenzoyl)-5-hydroxy-3-methoxybenzoate.(1),3'-dihydroxy-5,5'-dimethyldiphenyl ether(2),7,8-이갑기분병[g]접정-2,4(1H,3H)-이동(3),5-o-methylbostrycoidin (4)。초보약리활성현시화합물1대인체간암세포hepG2억제적IC50치위25μg·mL-1。소유화합물균수차종남해홍수림내생진균ZH-3중분리득도。
Secondary metabolites of mangrove endophytic fungus No. ZH-3 from South China sea were studied. The compounds were isolated by column chromatography and identified on the basic of physic-chemical constants and spectral analysis. Four metabolites were obtained and elucidated as 2-(3-chloro-2,6-dihydroxy-4-methylbenzoyl)-5-hydroxy-3-methoxybenzoate. (1),3,3’-dihydroxy-5,5’-dimethyldiphenylether(2), 7,8-dimethylbenzo[g]pteridine-2,4(1H,3H)-dione (3), 5-o-methylbostrycoidin (4). In the preliminary bioassay, 1 show inhibittory activity on the hepG2 cell line with IC50values of 25μg/mL. The four metabolites were obtained from endophytic fungus No. ZH-3 for the ifrst time.