CAJ | 학술논문

抑郁症作为主要的致残疾病预计到2020年将成为全球第2大疾病负担。随着研究的深入，该病的发病机制也从“单胺类递质假说”向“神经营养假说”及“增强神经发生作为抗抑郁手段”的认识转变，为发现新型抗抑郁调节因子带来了希望。大量研究表明神经肽VGF参与海马神经发生及神经可塑性的的调节，对神经元的增殖与存活功能发挥着重要调节作用，表明神经肽VGF有望成为一种新型抗抑郁调节因子。本文将对近年来神经肽VGF在神经发生、神经营养及突触活动的调控机制进行综述，进一步为研究以神经肽VGF为靶标的新型抗抑郁药物提供了新思路。
억욱증작위주요적치잔질병예계도2020년장성위전구제2대질병부담。수착연구적심입，해병적발병궤제야종“단알류체질가설”향“신경영양가설”급“증강신경발생작위항억욱수단”적인식전변，위발현신형항억욱조절인자대래료희망。대량연구표명신경태VGF삼여해마신경발생급신경가소성적적조절，대신경원적증식여존활공능발휘착중요조절작용，표명신경태VGF유망성위일충신형항억욱조절인자。본문장대근년래신경태VGF재신경발생、신경영양급돌촉활동적조공궤제진행종술，진일보위연구이신경태VGF위파표적신형항억욱약물제공료신사로。
As a major cause of disability, depression is expected to become the second highest burden of disease worldwide by the year 2020. The shift of research in depression from monoamine hypothesis to the realm of neurotrophic hypothesis, neural plasticity hypothesis, and enhancing neurogenesis as an antidepressant-like agent brings about crucial insights to find novel mediator of antidepressant activity. Studies have shown that the neuropeptide VGF participates in the regulation of hippocampal neurogenesis and neuroplasticity and also plays an important role in the regulation of neuronal proliferation and survival, suggesting that the neuropeptide VGF may be a novel regulator in antidepressant treatment. The authors review the latest progress in the regulatory mechanisms of neurpeptide VGF on neurogenesis, neurotrophic and synaptic activity in depression. Further understanding of the role of neuropeptide VGF in depression can identify novel targets for pharmacological interventions.